Papulosquamous Disorders Flashcards
Psoriasis definition
Chronic, inflammatory skin condition
Psoriasis age
Can be seen at any age, peak diagnosis in early 20s and middle age
Psoriasis morphologies
Plaque, guttate, inverse/flexural, generalized/erythrodermic, pustular, acral/palmoplantar, Auspitz sign, nail pitting
Psoriasis histology
Regular acanthosis, hyperkeratosis, parakeratosis with neutrophils and diminished granular layer, thinning of supra papillary plate with dilated capillaries
Psoriasis topical treatments
Corticosteroids, calcipotriene, retinoids, coal tar, calcineurin inhibitors
Psoriasis systemic treatments
Phototherapy, retinoids, immunomodulators, biologics
Psoriasis associated diseases
Psoriatic arthritis and increased risk of cardiovascular disease
Atopic dermatitis defintion
Chronic, inflammatory skin condition
Atopic dermatitis age
Typically diagnosed in infancy/early childhood
Atopic dermatitis morphology
Pruritus, papulosquamous eruptions on knees, elbows, forehead and cheeks of infant, more acral locations in children (neck, groin, elbows, wrist, ankles, back of knee, eyes, forehead)
Atopic dermatitis histology
Spongiosis, edema, parakaratosis, hyperplasia
Atopic dermatitis associated diseases
Food allergy, atopic rhinitis, asthma, AKA atopic march
Atopic dermatitis treatment
Gentle skin care/barrier, anti-inflammatories, addressing the itch-rash cycle, preventing triggers
Contact dermatitis definition
Inflammatory reaction caused by an externally applied substance
Contact dermatitis - allergy cause
Contact with substance causes a delayed hypersensitivity reaction, previous exposure necessary
Contact dermatitis - irritant cause
Contact with substance causes immediate reaction, no previous exposure necessary, typically dosage dependent
Allergic contact dermatitis morphology
Pruritus, erythema, scale, vesicles or bullae, distributed in sites of exposure
Allergic contact dermatitis common causes
Poison ivy/poison oak, nickel, fragrance, neomycin
Allergic contact dermatitis histology
Spongiosis, lymphocytes and eosinophils in dermis, surface exudate, upper dermal edema
Allergic contact dermatitis evaluation
Patch testing
Allergic contact dermatitis treatment
Avoidance, topical steroids, oral steroids, gentle skin care/emollients
Lichen planus morphology
Pruritic, purple, polygonal, planar papules (5 Ps), Wickham’s striae, koebnerizes, affects scalp, nails, genitals
Lichen planus histology
Band-like lymphocytic infiltrate along dermal epidermal junction with saw-tooth rete ridges
Lichen planus associated diseases
Hepatitis C, possibly metal dental work
Lichen planus treatment
Topical steroids, antihistamines
Lichen planus oral involvement
Wickham’s striae, erosions or ulcers, higher risk for oral cancer
Pityriasis rosea definition
Acute exanthem
Pityriasis rosea age
Younger people
Pityriasis rosea morphology
Starts with herald patch, then monomorphic eruption of papule in relaxed tension lines (Christmas tree pattern)
Pityriasis rosea histology
Parakeratosis, spongiosis, mild lymphocytic exocytosis, red cell extravasation, superficial perivascular infiltrate, regular acanthosis
