Paper 3 : Schizophrenia Flashcards
Schizophrenia diagnosis
ICD 11 : 2 negative symptoms
DSM-5 : 1 positive symptom
Hallucinations
Extra sensory experience eg voices
Delusions
Beliefs with no basis in reality
Avoiltion
Severe loss of motivation
Speech poverty
Reduced amount, speed and quality of speech
Symptom overlap
Same symptom in different conditions
Co morbidity
Occurrence of two conditions at the same time
Hyperdopaminergia
High activity of dopamine in sub cortex linked to hallucinations
Hypodopaminergia
Low activity in prefrontal cortex linked to disordered thinking
Neural correlates
Brain scans show structural abnormality and abnormal functioning in different areas of the brain linked with symptoms of SZ
Enlarged ventricles
Low activity in ventral striatum (linked to a avoilition)
Low activity in superior temporal gyrus (hallucinations)
Typical antipsychotic
Older
Chlorpromazine
400-800mg
Risk of agranulocytosis
Atypical
Newer
Risperidone
4-8mg
Also affects serotonin transmission
Family dysfunction
Due to family experiences of conflict, communication problems, criticism and control
Schizophrenogenic mother
Mother is cold and controlling and rejecting. Father is passive and not involved. Stress triggers psychotic thinking
Double bind communication
Bateson
Child receives mixed messages. Makes lots of mistakes, cannot do right thing. Punishment is withdrawal of love. Results in disorganised thinking and paranoia