Pancreas Flashcards
Physically describe the pancreas
Elongated, triangular (in x.s.) gland, 5” long, retroperitoneal
How is the pancreas supplied with blood?
Celiac Trunk → Splenic artery → Pancreatic artery
The endocrine pancreas is __% of it’s volume, and these cells are called the …
1%
Islets of Langerhans
In the exocrine pancreas, cells in each ______ produce pancreatic juice
acinus
How much pancreatic juice is made in a day?
1200-1500 ml/day
Describe pancreatic juice
a clear, colorless fluid, H2O, salts, bicarb, enzymes
What three things does pancreatic juice do?
1- Buffers HCl with bicarb
2- Stop action of pepsin
3- Create proper pH for small intestine enzymes
Which pancreatic enzyme digest carbohydrates and starch?
Pancreatic amylase
Which pancreatic enzyme digests lipids?
Pancreatic lipase
What does colipase do?
Anchors pancreatic lipase to fat droplets
Trypsinogen (via enterokinase) →
Trypsinogen (via enterokinase) → trypsin
Chymotrypsinogen (via trypsin) →
chymotrypsin
Procarboxypeptidase (via trypsin) →
carboxypeptidase
What digests RNA?
Ribonuclease
What digests DNA?
Deoxyribonuclease
What is a small fold of mucosa at entrance of duodenal wall at the pancreatic duct?
major duodenal papilla
What is a small fold of mucosa at entrance of duodenal wall at the accessory pancreatic duct?
minor duodenal papilla
The ________ ampulla, where bile duct meets pancreatic duct, turns into sphincter of _____.
Hepatopancreatic
Oddi
What two general mechanisms regulate pancreatic functions?
Neuroogical and hormonal
In cephalic and gastric stages of gastric digestion, _____ impulses also go to pancreas, so _____ pancreatic secretions– Gets ready for acid with ______.
PNS
↑
bicarb
When acidic chyme enters the small intestine enteroendocrine cells in duodenum secrete the hormone secretin, so __ pancreatic juice rich in bicarb ions
↑
When fats and proteins enter the small intestine other enteroendocrine cells secrete CCK, so __ pancreatic juice rich in digestive enzymes and ejection of bile.
↑
