pain and anesthetics #8

Question 1

Congenital analgesia?

Answer 1

Cannot feel pain, but can feel touch, not always Temp.

Question 2

Men have more?

Women have more?

Answer 2

back pain, cluster headaches

Migraines, UTIs, carpal tunnel

Question 3

Acute pain vs Chronic (% of pop.)?

Answer 3

Results from inflammation/injury and goes away, other persist. 25 >65years old

Question 4

Can Pain become a disease?

Answer 4

Yes when touches spinal cord and rewires itself

Question 5

Lebenswecker?

Answer 5

Tool to riderect pain with needles.

Question 6

Morpheus god of?

Answer 6

Sleep

Question 7

%of women orthopedic surgeons nowaday?

Answer 7

5-10%

Question 8

1st anesthetic? Possible founders?

Answer 8

EtOH heated with acid = Sweet vitriol = Ether/Diethyl ether + H2O
Raymunus 1200s
Paracelsus

Question 9

Joseph Priestley 1772 first to make? How?

Answer 9

N2O/Nitrous oxide. Heat ammonium nitrate (fertilizer and explosive) -> N2O + 2 H2O

Question 10

Sir Humprey Davy 1800s discovered?

Answer 10

Breath N2O = euphoric effect (Whipping cream)

Question 11

William T.G. Morton 1844?
Horace Wells 1844?
Is an example of?

Answer 11

Used ether inhaler in op.
First, op with N2O (tooth removal)
Simultaneous discovery

Question 12

Dr. Crawford Long 1848?

Answer 12

First, op with ether

Question 13

Letheon=

Answer 13

Ether

Question 14

John Collin William 1840s

Answer 14

Let Morton use anesthetics when he operated

Question 15

2 biggest op in 1800s?

Answer 15

Amputation, surface tumors

Question 16

Humbug?

Answer 16

When pt left during b/c too much pain.

Question 17

Press celebrated ether as?

Answer 17

Diminishing pain

Question 18

Who and how he killed houdini?

Answer 18

McGill student by punching him in the stomach and supposedly caused him an appendicitis .

Question 19

Robert Houdini supposedly?

Answer 19

Used ether to induce euphoria to public during levitation.

Question 20

James Simpson invented? date

Answer 20

Chloroform 1847

Question 21

Queen Victoria 1853 was the first to?

Answer 21

Anesthetized during 8th child, contreversy at the time

Question 22

Apoplexy=

Answer 22

uncounsciousness or incapacity = stroke

Question 23

Who gets most credit for discovery of anesthetics?why?

Answer 23

Dr. Crawford Long, b/c he published

Question 24

Other early anesthetic?

Answer 24

Potassium Bromide

Question 25

Dr. Harold Randall Griffith?

Answer 25

1st to used curare in operation in 1942 at McGill

Question 26

Curare plant?

Answer 26

Chondrodendron Tomentosum

Question 27

Preanesthetics Rx.

Answer 27

``` Atropine = block secretions Demerol = sedation ```

Question 28

Iv anethetics?

Answer 28

Tiopental sodium; fentanyl (100% more potent then morphine)

Question 29

Basic structure of opioids?

Answer 29

Benzene ring + 2 C + N

Question 30

2016 dead opiod overdose USA?

Answer 30

65 000, more than car

Question 31

Subsys?

Answer 31

Spray fentanyl

Question 32

1890 lancet physician opinion on hemp?

Answer 32

Best pain managment

Question 33

Propofol comes from?

Answer 33

Thymol (found in listerine) close to phenol

Question 34

Ane. mac of action?

Answer 34

Not clear, change in neurons membranes transmission

Question 35

Poppy exsudat [] %?

Answer 35

10% morphine, 19% codeine

Question 36

TReat, addict in myanmar?

Answer 36

Public vomiting

Question 37

Heroin world prod?

Answer 37

Afghanistan and Myanmar

Question 38

2001 in afgha?

Answer 38

Fatwa on heroin, prod decreased, now back up.

Question 39

Found in urine after poppy and heroin intake

Answer 39

Thebaine

Question 40

Laudanum=

Answer 40

opium

Question 41

Andersonville Prison Gergio during civil war 1860?

Answer 41

Morphine was brought to ease pain

Question 42

Anecdote of Dr. HArold Shipmen?

Answer 42

Killed more than 200 women using morphine

Question 43

effort to control oxycodone?

Answer 43

RFID on bottle

Question 44

Morphine isolated in? | Synthetized in?

Answer 44

1805 | 1942

Question 45

2 acetyl group on morphine =?

Answer 45

Heroin, quicker high, converted into morphine in the body

Question 46

Opioids ant?

Answer 46

Naltrexone/naloxone

Question 47

Bernard Belleau mcgill invented?

Answer 47

Stradol (Butorphanol), less addiction, vet. use

Question 48

Endogenous opiods formation?

Answer 48

B-Lipotropin (polypeptide) ->Endorphin | Enkephalin (cannot be given in pills)

Question 49

PLacebo?

Answer 49

Expectation of pain relief = open u-opiod receptor

Question 50

GAte control theory?

Answer 50

Pain signal interfered by stimulating nerve ending responsible for pain, stimulating endoprhins

Question 51

Chinese red headed centiped?

Answer 51

Venom block Na+ channel linked to pain

Question 52

Comes from frog-epibatidine?

Answer 52

ABT-594 - as effective as morphine

Question 53

Comes from Cone Shell venom?

Answer 53

Zincontide, block pain channels, when put into spinal cord, 500X more potent than morphine