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Drugs 183 > pain and anesthetics #8 > Flashcards

pain and anesthetics #8 Flashcards

1
Q

Congenital analgesia?

A

Cannot feel pain, but can feel touch, not always Temp.

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2
Q

Men have more?

Women have more?

A

back pain, cluster headaches

Migraines, UTIs, carpal tunnel

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3
Q

Acute pain vs Chronic (% of pop.)?

A

Results from inflammation/injury and goes away, other persist. 25 >65years old

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4
Q

Can Pain become a disease?

A

Yes when touches spinal cord and rewires itself

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5
Q

Lebenswecker?

A

Tool to riderect pain with needles.

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6
Q

Morpheus god of?

A

Sleep

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7
Q

%of women orthopedic surgeons nowaday?

A

5-10%

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8
Q

1st anesthetic? Possible founders?

A

EtOH heated with acid = Sweet vitriol = Ether/Diethyl ether + H2O
Raymunus 1200s
Paracelsus

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9
Q

Joseph Priestley 1772 first to make? How?

A

N2O/Nitrous oxide. Heat ammonium nitrate (fertilizer and explosive) -> N2O + 2 H2O

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10
Q

Sir Humprey Davy 1800s discovered?

A

Breath N2O = euphoric effect (Whipping cream)

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11
Q

William T.G. Morton 1844?
Horace Wells 1844?
Is an example of?

A

Used ether inhaler in op.
First, op with N2O (tooth removal)
Simultaneous discovery

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12
Q

Dr. Crawford Long 1848?

A

First, op with ether

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13
Q

Letheon=

A

Ether

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14
Q

John Collin William 1840s

A

Let Morton use anesthetics when he operated

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15
Q

2 biggest op in 1800s?

A

Amputation, surface tumors

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16
Q

Humbug?

A

When pt left during b/c too much pain.

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17
Q

Press celebrated ether as?

A

Diminishing pain

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18
Q

Who and how he killed houdini?

A

McGill student by punching him in the stomach and supposedly caused him an appendicitis .

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19
Q

Robert Houdini supposedly?

A

Used ether to induce euphoria to public during levitation.

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20
Q

James Simpson invented? date

A

Chloroform 1847

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21
Q

Queen Victoria 1853 was the first to?

A

Anesthetized during 8th child, contreversy at the time

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22
Q

Apoplexy=

A

uncounsciousness or incapacity = stroke

23
Q

Who gets most credit for discovery of anesthetics?why?

A

Dr. Crawford Long, b/c he published

24
Q

Other early anesthetic?

A

Potassium Bromide

25
Q

Dr. Harold Randall Griffith?

A

1st to used curare in operation in 1942 at McGill

26
Q

Curare plant?

A

Chondrodendron Tomentosum

27
Q

Preanesthetics Rx.

A 
Atropine = block secretions
Demerol = sedation
28
Q

Iv anethetics?

A

Tiopental sodium; fentanyl (100% more potent then morphine)

29
Q

Basic structure of opioids?

A

Benzene ring + 2 C + N

30
Q

2016 dead opiod overdose USA?

A

65 000, more than car

31
Q

Subsys?

A

Spray fentanyl

32
Q

1890 lancet physician opinion on hemp?

A

Best pain managment

33
Q

Propofol comes from?

A

Thymol (found in listerine) close to phenol

34
Q

Ane. mac of action?

A

Not clear, change in neurons membranes transmission

35
Q

Poppy exsudat [] %?

A

10% morphine, 19% codeine

36
Q

TReat, addict in myanmar?

A

Public vomiting

37
Q

Heroin world prod?

A

Afghanistan and Myanmar

38
Q

2001 in afgha?

A

Fatwa on heroin, prod decreased, now back up.

39
Q

Found in urine after poppy and heroin intake

A

Thebaine

40
Q

Laudanum=

A

opium

41
Q

Andersonville Prison Gergio during civil war 1860?

A

Morphine was brought to ease pain

42
Q

Anecdote of Dr. HArold Shipmen?

A

Killed more than 200 women using morphine

43
Q

effort to control oxycodone?

A

RFID on bottle

44
Q

Morphine isolated in?

Synthetized in?

A

1805

1942

45
Q

2 acetyl group on morphine =?

A

Heroin, quicker high, converted into morphine in the body

46
Q

Opioids ant?

A

Naltrexone/naloxone

47
Q

Bernard Belleau mcgill invented?

A

Stradol (Butorphanol), less addiction, vet. use

48
Q

Endogenous opiods formation?

A

B-Lipotropin (polypeptide) ->Endorphin

Enkephalin (cannot be given in pills)

49
Q

PLacebo?

A

Expectation of pain relief = open u-opiod receptor

50
Q

GAte control theory?

A

Pain signal interfered by stimulating nerve ending responsible for pain, stimulating endoprhins

51
Q

Chinese red headed centiped?

A

Venom block Na+ channel linked to pain

52
Q

Comes from frog-epibatidine?

A

ABT-594 - as effective as morphine

53
Q

Comes from Cone Shell venom?

A

Zincontide, block pain channels, when put into spinal cord, 500X more potent than morphine

Drugs 183 (13 decks)

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