Class#3 - Toxicology

Question 1

Junk food contains

Answer 1

Dioxins

Question 2

Bread

Answer 2

Acrylamide

Question 3

Chlorinated water

Answer 3

trihalomethane

Question 4

Polyester bottled water

Answer 4

Antimony

Question 5

Nail polish

Answer 5

Dibutyl Phtalate

Question 6

POlyeruthane pillows

Answer 6

Isocyanates

Question 7

Rubber

Answer 7

Nitrosamines

Question 8

ADL determined by

Answer 8

1/100th of NOAEL

Question 9

Discovered curare caused musc. relaxation

Answer 9

Sir Charles Waterton

Question 10

Discovered curare blocks nerve impulse from CNS

Answer 10

Claude Bernard

Question 11

1st to use curare in surgery

Answer 11

Dr. Harold Griffith in 1942 in Mtl

Question 12

Sulfanilamide use and problem, b/c of who? Led to?

Answer 12

ATB for gonorrhea/strep troat, disolved in diethyl Glycol by Watkins. 1938 Food and Cosmetic Act

Question 13

Sulfanilamide mixture killed?

Answer 13

107, mostly childs and 206 desabilities

Question 14

Who connected death to diethyl glycol?

Answer 14

Frances Kelsey (McGill)

Question 15

Hormesis?

Answer 15

Study Rx at very low doses

Question 16

Super smal dose toxic eg?

Answer 16

Vit. A also BPA

Question 17

Risk=

Answer 17

Exposure * Toxicity

Question 18

Lima beans contains?

Answer 18

Cyanide

Question 19

Cassava fruits contains?

Answer 19

Toxic dose of cyanide, lethal 10 000mcg

Question 20

Puffer fish

Answer 20

Tetrodotoxins lethal 10mcg

Question 21

Clostridium Botulism lethal dose

Answer 21

0.03mcg

Question 22

Chocolote toxic to animals b/c

Answer 22

Cannot metabolize theobromine

Question 23

Difficulties in toxicology?

Answer 23

Type of exposure, biochemical individualtity, Acute vs Chronic, Teratogenic effects, Toxins recognition, animal models

Question 24

BBQ meat froms

Answer 24

Benzopyrenes

Question 25

Inducing detox

Answer 25

Catechins in green tea, Glutathione-s-transferase in garlic, JOhn’s Wort stimulate P450

Question 26

Cyclosporine problem with?

Answer 26

jonhns wort

Question 27

Normal acéta metabolism?

Answer 27

Glucoronyl transferase

Question 28

When too much acéta?

Answer 28

p450 makes acéta into molecule that causes liver damage. N-Acétylcystéine ->Gluthathione-s-transferase detox.

Question 29

Enz. making bilirubin detox

Answer 29

Glucoronyl Transferase

Question 30

1st non-sedating antihistamine, however with… accumulates.

Answer 30

Seldane, Ketoconazole

Question 31

Allegra is?

Answer 31

Metabolic active form of seldane

Question 32

What in grapefruit inhibits p450?

Answer 32

Furanocoumarins

Question 33

Age cheese contains? bad with MAOI b/c?

Answer 33

Tyramine, increase BP if not broken down by MAO

Question 34

Dioxins all contains?

Answer 34

Central oxygen with 4 cl

Question 35

Toxic dioxin?

Answer 35

TCDD

Question 36

dioxins come from?

Answer 36

Auxins, are plant growth hormone

Question 37

TCDD byproduct of?

Answer 37

2,4,5 - T