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Drugs 183 > Class#3 - Toxicology > Flashcards

Class#3 - Toxicology Flashcards

1
Q

Junk food contains

A

Dioxins

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2
Q

Bread

A

Acrylamide

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3
Q

Chlorinated water

A

trihalomethane

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4
Q

Polyester bottled water

A

Antimony

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5
Q

Nail polish

A

Dibutyl Phtalate

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6
Q

POlyeruthane pillows

A

Isocyanates

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7
Q

Rubber

A

Nitrosamines

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8
Q

ADL determined by

A

1/100th of NOAEL

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9
Q

Discovered curare caused musc. relaxation

A

Sir Charles Waterton

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10
Q

Discovered curare blocks nerve impulse from CNS

A

Claude Bernard

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11
Q

1st to use curare in surgery

A

Dr. Harold Griffith in 1942 in Mtl

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12
Q

Sulfanilamide use and problem, b/c of who? Led to?

A

ATB for gonorrhea/strep troat, disolved in diethyl Glycol by Watkins. 1938 Food and Cosmetic Act

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13
Q

Sulfanilamide mixture killed?

A

107, mostly childs and 206 desabilities

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14
Q

Who connected death to diethyl glycol?

A

Frances Kelsey (McGill)

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15
Q

Hormesis?

A

Study Rx at very low doses

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16
Q

Super smal dose toxic eg?

A

Vit. A also BPA

17
Q

Risk=

A

Exposure * Toxicity

18
Q

Lima beans contains?

A

Cyanide

19
Q

Cassava fruits contains?

A

Toxic dose of cyanide, lethal 10 000mcg

20
Q

Puffer fish

A

Tetrodotoxins lethal 10mcg

21
Q

Clostridium Botulism lethal dose

A

0.03mcg

22
Q

Chocolote toxic to animals b/c

A

Cannot metabolize theobromine

23
Q

Difficulties in toxicology?

A

Type of exposure, biochemical individualtity, Acute vs Chronic, Teratogenic effects, Toxins recognition, animal models

24
Q

BBQ meat froms

A

Benzopyrenes

25
Q

Inducing detox

A

Catechins in green tea, Glutathione-s-transferase in garlic, JOhn’s Wort stimulate P450

26
Q

Cyclosporine problem with?

A

jonhns wort

27
Q

Normal acéta metabolism?

A

Glucoronyl transferase

28
Q

When too much acéta?

A

p450 makes acéta into molecule that causes liver damage. N-Acétylcystéine ->Gluthathione-s-transferase detox.

29
Q

Enz. making bilirubin detox

A

Glucoronyl Transferase

30
Q

1st non-sedating antihistamine, however with… accumulates.

A

Seldane, Ketoconazole

31
Q

Allegra is?

A

Metabolic active form of seldane

32
Q

What in grapefruit inhibits p450?

A

Furanocoumarins

33
Q

Age cheese contains? bad with MAOI b/c?

A

Tyramine, increase BP if not broken down by MAO

34
Q

Dioxins all contains?

A

Central oxygen with 4 cl

35
Q

Toxic dioxin?

A

TCDD

36
Q

dioxins come from?

A

Auxins, are plant growth hormone

37
Q

TCDD byproduct of?

A

2,4,5 - T

Drugs 183 (13 decks)

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