Final

Question 1

Gaucher disease drug does what?

Answer 1

Glucocerebroside builds up attack WBC, b/c lack Enz. Imiglucerase to convert it to glucose ceramide which is inoffensive. Cerezyme 25 000$ a month replace the imiglucerase.

Question 2

Tool to redirect pain?

Answer 2

Lebenswecker

Question 3

Possible founder of first anesthetics

Answer 3

Raymond 1200s, sweet vitriol, possibly contained diethyl ether

Question 4

First to make N2O

Answer 4

Joseph Priestley 1772, by heating ammonium nitrate

Question 5

Discovered breathing N2O euphoric effects?

Answer 5

Sir Humprey Davy 1800s

Question 6

Simultaneous discovery of anesthetics used in surgery?

Answer 6

William T.G. Morton used ether 1844 to operate on John Collin William
Horace Wells used N2O for tooth removal 1844

Question 7

Credited with the discovery of ether?

Answer 7

Dr. Crawford Long 1848 he published

Question 8

Inventor of chloroform

Answer 8

James Simpson 1847

Question 9

1st to used curare in operation

Answer 9

Dr. Harold Griffith 1942

Question 10

Found in urine after poppy intake

Answer 10

Thebaine

Question 11

Bernard Belleau (McGill) invented?

Answer 11

Stadol - Butorphanol

Question 12

Chinese red-headed centipede venom action

Answer 12

Block NA+ channel linked to pain

Question 13

Frog Epibatidine potent component?

Answer 13

ABT-594 = morphine

Question 14

Cone Shell venom

Answer 14

Ziconotide = 500X potent than morphine

Question 15

OTTA Loewi 20s discovered?

Answer 15

Stimulation vagus nerve in frog slowed HR. Discovered Neurotransmitters (acetylcholine)

Question 16

Who hypothesized death during surgery due to histamine? TRied? Found out what and did what with that?

Answer 16

Henry Laborit (1952). Promethazine (Phenergan), calmed pts and worked on schizo. Triggered research.

Question 17

Henri Laborit successful Rx?

Answer 17

Chlorpromazine, block dopamine, schizo due to excess dopamine, AE: Parkinson like syndrome.

Question 18

Who tried Reserpine on schizo?

Answer 18

Nathan Kline in the US and it worked.

Question 19

Discovery of first Tricyclics?

Answer 19

research for improved Chlorpromazine -> Imipramine.

Question 20

First SSRIs

Answer 20

Prozac

Question 21

Meds for OCD?

Answer 21

SSRIs