Pain Flashcards
What is the sensory aspect of pain?
discriminative
what is the cognitive aspect of pain?
evaluative
what is the affective aspect of pain?
emotional
what can the relationship between input and experience be dependant on?
genetics demographics previous damage and dysfunction emotional context pyschological state
What is the neuroplasticity theory of pain?
nervous system changes at the periphery, nerve axons, spinal chord and brain
what is nocioceptive pain?
physiologic response to painful stimuli via intact nervous system
what is neuropathic pain?
an innappropriate response caused by a dysfunction in the nervous system
What is acute pain?
usually obvious tissue damage
protective function
increased nervous activity
pain resolves on healing
What is chronic pain?
pain beyond period of healing
pain does not serve purpose
changes in pain signalling and detection
degrades health and function
what pharmacological approaches can be used for chronic pain management?
non opiod analgesics opiod analgesics antidepressants anticonvulsants topical analgesics
Name non opiod analgesics
NSAIDS, paracetamol
name opiod analgesics
tramadol, codeine, morphine, oxycodone
name antideppressants re. chronic pain
amytryptyline, duloxetine
name anticonvulsants re. chronic pain
gabapentin, pregabalin
name topical analgesics
capsaicin, lidocaine plaster
what do NSAIDS act on?
nocioceptive pain
what are NSAIDS not indicated for?
neuropathic pain
what do NSAIDS inhibit?
cyclooxygenase
what decreases with the use of NSAIDS?
prostoglandin synthesis
What are the side effects of the use of NSAIDS?
GI irritation
renal toxicity
potential drug interactions
cardiovascular side effects
What effects does paracetamol have?
amalgesic and antipyretic
does paracetamol have anti inflammatory action?
no
what does paracetamol inhibit?
central prostaglandin synthesis
what are side effects of paracetamol?
risk of toxic liver damage`
