Pain Flashcards
• Pain is protective
– Brings into consciousness the awareness of tissue damage
• Pain doesn’t feel protective
– It is accompanied by motivational and behavioral responses:
• Crying,Fear, Withdrawal
Physiology of Pain
– Mechanical nociception • Mechanical damage to body tissue – Thermal nociception • Damage due to temperature exposure – Polymodal nociception • General category • Pain triggers chemical reactions from tissue damage
(pain perception) NOCICEPTION
conveys information about the senses to and from the brain[all motor nerves to skeletal muscles]
Somatic nervous system
convey info about the sense organs to the CNS
Afferent (sensory) neurons
convey info from CNS to muscles, organs, and glands
Efferent (motor) neurons
connect sensory to motor neurons
Interneurons
all motor nerves to smooth and cardiac muscles, galnds
autonomic system
Nociceptors in peripheral nerves first sense ____
injury
In response, release chemical messengers
which travel to spinal cord and brain ,____ neurons
afferent
Brain regions identify the site of the injury and
send messages back down spinal column, ____ neurons
efferent
• Leads to muscle contractions, helps block pain
• Changes in other bodily functions, such as
breathing
nociceptors
- Acts in spinal cord
* Involved in the transmission of pain impulses from peripheral receptors to the CNS
Substance P
- Acts in spinal cord
- Amplifies pain signal transmitted from spinal cord to brain
- Implicated in chronic pain
– Glutamate
- Released by tissue damage
* Prolong the experience of pain by continued stimulation of nociceptors
Bradykinin & prostaglandins
- Released by the immune system to signal the nervous system
- Produce responses such as decreased activity, increased fatigue, increased pain sensitivity
- May sensitize structures in the dorsal horn of the spinal cord to promote the development of chronic pain
Inflammatory cytokines
Head and neck pain is directly transmitted to
brain via the 12 ____ nerves
cranial
For the rest of the body, the peripheral nervous
system must send impulses to the brain via ___ ___
spinal cord
small, myelinated fibers that transmit sharp
pain
• Especially mechanical or thermal pain
• Regulate sensory aspects of pain by projecting onto areas of the
thalamus and sensory areas of the cortex
A-DELTA fibers
– large, myelinated fibers
• Conduct impulses 100x faster than C-fibers
• Easily stimulated
A-BETA fibers
– unmyelinated fibers transmit dull, aching pain
• >60% of all sensory afferents
• Require more stimulation
• Polymodal pain
• Regulate affective and motivational elements of pain by projecting onto thalamic, hypothalamic, and cortical areas
C-fibers
- Primary & secondary somatosensory cortices
- Anterior cingulated cortex (ACC)
- Thalamus
- Cerebellum
Brain areas involved in pain: