Paget's Disease Flashcards
1
Q
what is it?
A
Abnormal osteoclastic activity which is followed by increased osteoblastic activity
abnormal bine structure with reduced strength and increased fracture risk
can be a single site - monostatic or multiple sites - polyostotic
2
Q
who gets it?
A
can be a viral, environmental or biomechanical trigger in genetically predisposed individuals
increased incidence with age
3
Q
what bones does it affect?
A
long bones
pelvis
lumbar spine
skull
4
Q
how does it present?
A
bone pain deformity deafness compression neuropathies osteosarcoma - rare complication can be an incidental x-ray finding or isolated high alkaline phosphate
5
Q
how is it diagnosed?
A
x-ray
isotope bone scan shows disease distribution
biochemistry shows raised alkaline phosphate with otherwise normal LFTs
6
Q
how is it managed?
A
bisphosphate
pain can be treated with analgesia if unresponsive
