Oxazolidinones Flashcards
What are the agents that fall under oxazolidinone class?
- Linezolid
- Tedizolid
(T/F) - Tedizolid is a useful IV/PO antibiotic for the treatment of various resistant gram (+) infections
FALSE - Linezolid is
(T/F) - Tedizolid is a novel agent IV/PO antibiotic that is currently indicated only for acute bacterial skin/skin structure infections
TRUE
What is the MOA of oxazolidinones?
- Inhibits bacterial protein synthesis by binding to the bacterial 23s ribosomal RNA of the 50s subunit preventing the formation of a functional 70s initiation complex that is essential for the bacterial translation process
(T/F) - Oxazolidinones are bacteriostatic against enterococci, streptococci, and most staphylococci
FALSE - bacteriostatic against enterococci, staphylococci, and most strains of streptococci
What is the mechanism of resistance of oxazolidinones?
Mutation of the 23s ribosomal RNA
Oxazolidinones have a good spectrum in which bacteria?
- MRSA
- MSSA
- Streptococci (including MDR of S. pneumonia)
- Enterococci (including VRE)
What are common adverse events that could occur in linezolid?
- Bone marrow suppression (thrombocytopenia)
- Peripheral neuropathy
- Lactic acidosis
Why does bone marrow suppression occur in linezolid?
Because of the long-term use of therapy (> 2 weeks)
Why does peripheral neuropathy and lactic acidosis occur?
Because of the long-term use of therapy due to toxicity of mitochondria
What are the common adverse events that could occur in tidezolid?
- N/V/D
- HA
What is the percentage of bioavailability in both oxazolidinones given PO?
> 90%
Both oxazolidinones are reversible inhibitors of what enzymes?
Monoamine oxidase
Oxazolidinones can cause what adverse event when given with SSRIs?
Serotonin syndrome - avoid concomitant use as possible
(T/F) - Oxazolidinones do not need renal adjustments for renal dysfunction pts, but need hepatic adjustments for hepatic dysfunction pts
FALSE - do not need renal or hepatic adjustments for both drugs
