Osteoporosis Medications Flashcards
generic name
fosamax, binosto
alendronate
class for alendronate
biphosphonates
MOA
biphosphonates
binds to bone hydroxyapatite and inhibits osteoclast activity
↓ bone resorption, modulates bone metabolism, ↑ bone mineral density
contraindications
biphosphonates
- hypocalcemia
- esophageal abnormalities
- inability to stand or sit upright for at least 30 minutes
common ADRs
biphosphonates
- nausea/vomiting
- dyspepsia
- decreased levels of serum calcium
rare ADRs
biphosphonates
- atypical femur fracture
- osteonecrosis of the jaw
- GI ulcer
key counseling points
biphosphonates
- Take first thing in the morning, ≥30 minutes before the first food, beverage (except plain water), or other medication(s) of the day
- Remain upright for ≥30 minutes after taking to reduce esophageal irritation
other top 300 meds
biphosphonates
- brand: boniva, generic: ibandronate
- brand: actonel & atelvia, generic: risedronate
brand name
selective estrogen receptor modulators (SERMs)
evista
generic name
selective estrogen receptor modulators (SERMs)
raloxifene
MOA
selective estrogen receptor modulators (SERMs)
Binds to estrogen receptors, resulting in activation of estrogenic pathways in some tissues (agonism) and blockade of estrogenic pathways in others (antagonism)
Acts as an estrogen agonist in bone, decreasing bone resorption and bone turnover and increasing BMD (bone mineral density)
contraindications
selective estrogen receptor modulators (SERMs)
- pregnancy
- current or history of thromboembolic disorders
black box warnings
selective estrogen receptor modulators (SERMs) evista
- ↑ Risk of VTE (venous thromboembolism)
- ↑ Risk of Stroke
common ADRs
selective estrogen receptor modulators (SERMs)
- hot flashes
- arthralgia
- leg cramps
- peripheral edema
rare but serious ADRs
selective estrogen receptor modulators (SERMs)
- VTE
- hypertriglyceridemia
- stroke
- pulmonary embolism
