Glucocorticoids

Question 1

generic name

glucocorticoids

Answer 1

prednisone

Question 2

brand name

glucocorticoids

Answer 2

deltasone

Question 3

indication

prednisone (glucocorticoids)

Answer 3

treat many conditions that are caused by inflammation

Question 4

MOA

prednisone (glucocorticoids)

Answer 4

This mechanism results in the suppression of proinflammatory molecules called transrepression and upregulation of many anti-inflammatory molecules called transactivation.

Question 5

common ADRs

prednisone (glucocorticoids)

Answer 5

GI side effect

Question 6

rare but serious ADRs

prednisone (glucocorticoids)

Answer 6

• Primary adrenocortical insufficiency
• Cushing’s syndrome
• decrease body growth
• increased risk of infection

Question 7

contraindications

prednisone (glucocorticoids)

Answer 7

• fungal infections
• administration of live vaccine

Question 8

key counseling points

prednisone (glucocorticoids)

Answer 8

• Take with food or milk to prevent GI upset
• Take in the morning to help prevent insomnia
• For high-dose or longer-term treatment, monitor for signs of hyperglycemia, osteoporosis, adrenocortical insufficiency, and infection
• Avoid abrupt discontinuation treatment duration > 3 weeks and dose > 20 mg prednisone equivalent