Antidepressants Flashcards
generic name and class
brand: Elavil
generic: amitriptyline
class: tricyclic antidepressant (TCA)
brand name and class
generic: Doxepin
brand: sinequan, silenor
class: tricyclic antidepressant (TCA)
generic name and class
brand: Pamelor
generic: Nortriptyline
class: tricyclic antidepressant (TCA)
brand name and class
generic: Citalopram
brand: Celexa
class: selective serotonin reuptake inhibitor (SSRI)
generic name and class
brand: lexapro
generic: escitalopram
class: selective serotonin reuptake inhibitor (SSRI)
brand name and class
generic: fluoxetine
brand: prozac, sarafem
class: selective serotonin reuptake inhibitor (SSRI)
brand name and class
generic: paroxetine
brand: paxil, paxil cr
class: selective serotonin reuptake inhibitor (SSRI)
generic name and class
brand: zoloft
generic: sertraline
class: selective serotonin reuptake inhibitor (SSRI)
brand name and class
generic: desvenlafaxine
brand: pristiq, khedezla
class: serotonin norepinephrine reuptake inhibitor (SNRI)
brand name and class
generic: duloxetine
brand: cymbalta
class: serotonin norepinephrine reuptake inhibitor (SNRI)
generic name and class
brand: effexor, effexor xr
generic: venlafaxine
class: serotonin norepinephrine reuptake inhibitor (SNRI)
generic name and class
brand: aplenzin, forfivo, wellbutrin, zyban
generic: bupropion
class: miscellaneous AD
generic name and class
brand: remeron
generic: mirtazapine
class: miscellaneous AD
brand name and class
generic: vilazodone
brand: viibryd
class: miscellaneous AD
MOA for TCAs
amitriptyline, doxepin, nortriptyline
inhibit reuptake of norepinephrine and serotonin
MOA for SSRIs
citalopram, escitalpram, fluoxetine, paroxetine, and sertraline
inhibits reuptake of serotonin
MOA for SNRIs
desvenlafaxine, duloxetine, and venlafaxine
serotonin norepinephrine reuptake inhibitors
MOA for AD-misc
bupropion, mirtazapine, and vilazodone
Bupropion: NE-DA
Mirtazapine: 5HT/NE-hist
Vilazodone: 5HT
contraindications for SSRIs
citalopram, escitalpram, fluoxetine, paroxetine, and sertraline
concomitant use of MAOIs
BBW for SSRIs
citalopram, escitalpram, fluoxetine, paroxetine, and sertraline
suicidality
ADRs for TCAs
amitriptyline, doxepin, nortriptyline
- sedation
- seizure
- anticholinergic effects
- CV heart block
- orthostatic hypotension
- tachycardia
ADRs for SSRIs
citalopram, escitalpram, fluoxetine, paroxetine, and sertraline
- abnormal bleeding, hyponatremia
- serotonin syndrome
- seizures
- activation of mania
- angle closure glaucoma
- discontinuation syndrome
- sexual dysfunction
ADRs for SNRIs
desvenlafaxine, venlafaxine, and dulxetine
- abnormal bleeding
- hyponatremia
- serotonin syndrome
- seizures
- activation of mania
- angle closure glaucome
- discontinuation syndrome
- suicide boxed warning
- sexual dysfunction
- elevated blood pressure
ADRs for AD-misc
bupropion, mirtazapine, and vilazodone
- suicide boxed warning
- activation of mania
- CYP drug interactions
key counseling points
all ADs
- takes up to 4-6 weeks to take effect
- side effects like stomach upset, nausea and diarrhea should decrease with continued use. feeling anxiety with first few doses is common
- sexual side effecrs are common and don’t resolve with continued use
- contact MD if changes in mood, thinking or behavior
- do not drive or operate machinery after first dose until you know how meds will affect you
- if med makes you drowsy take at bedtime. if med makes you restless take in morning w/o regard to food at either time of day
- do not take other meds without checking with MD or RPh
- avoid alcohol and recreational substances
