Antigout Flashcards
brand name
allopurinol (xanthase oxidase inhibitor)
zyloprim
indication
allopurinol (xanthase oxidase inhibitors)
gout, hyperuricemia, tumor lysis syndrome, kidney stones
MOA
allopurinol (xanthase oxidase inhibitors)
decrease uric acid production
common ADRs
allopurinol (xanthase oxidase inhibitors)
- diarrhea
- liver enzymes abnormality
- rash
- acute gouty arthritis
rare but serious ADRs
allopurinol (xanthase oxidase inhibitors)
- Stevens Johnson Syndrome (SJS)
- toxic epidermal necrolysis (TENS)
- aplastic anemia
- agranulocytosis
- hepatotoxicity
- renal failure
contraindications
allopurinol (xanthase oxidase inhibitors)
hypersensitivity, HLA-B 5801
key counseling points
allopurinol (xanthase oxidase inhibitors)
- take after meals to alleviate GI symptoms
- drink plenty of water to prevent kidney stones
- avoid alcohol and caffeine
brand name
febuxostat (xanthase oxidase inhibitor)
uloric
indication
febuxostat (xanthase oxidase inhibitor)
hyperuricemia
MOA
febuxostat (xanthase oxidase inhibitor)
decrease uric acid production
common ADRs
febuxostat (xanthase oxidase inhibitor)
- diarrhea
- nausea
- acute gouty arthritis
rare but serious ADRs
febuxostat (xanthase oxidase inhibitor)
- ECG abnormalities
- stroke
- mood changes
- rash
contraindications
febuxostat (xanthase oxidase inhibitor)
concurrent use of azathioprine and 6-mercaptopurine
black box warning
febuxostat (xanthase oxidase inhibitor)
increased risk of death (cardiac, all-cause)
key counseling points
febuxostat (xanthase oxidase inhibitor)
- take with food
- seek medical attention for severe mood swings, rashes or abnormal heartbeat
brand name
colchicine (antigout agent)
colcrys, gloperba, mitigare
indication
colchicine (antigout agent)
gout, familial mediterranean fever
MOA
colchicine (antigout agent)
Unknown, may interferes with crystal
deposition in joint tissues and may inhibit locomotion and chemotaxis of neutrophils
common ADRs
colchicine (antigout agent)
- diarrhea
- nausea
rare but serious ADRs
colchicine (antigout agent)
- agranulocytosis
- rhabdomyolysis (esp. w/ lipid lower agent)
contraindications
colchicine (antigout agent)
use w/ strong CYP3A4/5 inhibitors in patients w/ renal or hepatic failure
key counseling points
colchicine (antigout agent)
- Take as instructed, dosing for acute and chronic gout are different.
- Dose dosing to symptom relief or onset of adverse effects, particularly diarrhea
- This drug may interact with your other medication
