Osteoporosis (Exam #3) Flashcards

1
Q

What four medications inhibit osteoclasts?

A
  • Estrogen
  • Calcitonin
  • Bisphosphonates
  • Denosumab
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2
Q

What two medications activate osteoblasts?

A
  • PTH

- Vitamin D

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3
Q

What two effects do ALL osteoporosis drug have?

A
  • Increase bone density

- Decrease osteoporotic fractures

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4
Q

What are the only two anabolic drugs used to treat osteoporosis? How do these differ?

A
  • Teriparatide = INTERMITTENT administration

- Abaloparatide

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5
Q

What is rhPTH used to treat?

A

Hypothyroidism

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6
Q

What is rhPTH used to treat?

A

Hypothyroidism

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7
Q

What are the four Bisphosphonates (think name hint), and what are their admin routes?

A

“-dronate”

  • Alendronate = oral
  • Risedronate = oral
  • Ibandronate = oral AND IV
  • Zoledronic Acid = IV
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8
Q

Important PK of Alendronate, Risedronate, Ibandronate, Zoledronic Acid? How does this change administration (2)?

A

Poor oral absorption

  • Take on empty stomach
  • Take with 1/2 glass of water ONLY
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