EXAM #2 AEs

Question 1

AE of Loops? Which is worse?

Answer 1

Ototoxicity

- Worse with Ethacrynic Acid

Question 2

AE of Loops AND Thiazides?

Answer 2

Hypokalemic alkalosis

Question 3

AE of Thiazides (2)? Exception?

Answer 3

• Hyperglycemia

- Increase lipids (except Indapamide)

Question 4

AE of ACE-I (2)?

Answer 4

• Dry cough

- Angioedema

Question 5

AE of Digoxin (2)?

Answer 5

• FIRST: GI

- Cardiac (bigeminy, VFib)

Question 6

What group of medications decrease glucose tolerance?

Answer 6

Diuretics

Question 7

AE of Clonidine AND Methyldopa (2)?

Answer 7

• Sedation

- Xerostomia

Question 8

AE of Methyldopa?

Answer 8

Hemolytic anemia (+Coombs)

Question 9

AE of Prazosin?

Answer 9

• First dose phenomenon

Question 10

AE of Labetolol?

Answer 10

Hepatotoxicity

Question 11

AE of Hydralazine?

Answer 11

HIP (slow acetylators)

Question 12

AE of Sodium nitroprusside? In what population especially?

Answer 12

CYANIDE

- Especially if kidney disease

Question 13

AE of Nifedipine (2)?

Answer 13

Worst for reflex tachycardia

- Gingival hyperplasia

Question 14

AE of Verapamil (2)?

Answer 14

• Constipation

- Cardiac depression

Question 15

AE of Nitrates? What if chronic use?

Answer 15

• Throbbing HA

Chronic: Monday disease

Question 16

AE of Sildenafil (2)?

Answer 16

• Drug interactions

- Visual impairment (blue light)

Question 17

AE of Statins (3)?

Answer 17

• Increase LFTs (liver issues)
• Increase CK (skeletal issues)
• Drug interactions (CYP3A4)

Question 18

AE of Niacin?

Answer 18

Flushing

Question 19

AE of Fibrates?

Answer 19

GALLSTONES

Question 20

AE of ALL Arrhythmics?

Answer 20

Arrhythmias

Question 21

What type of Arrhythmics cause Torsade de Pointe? Which two drugs cause it?

Answer 21

If APD increased = QT prolongation

• Quinidine
• Sotalol

Question 22

What drug does NOT cause Torsade de Pointe?

Answer 22

Amiodarone

Question 23

AE of Procainamide?

Answer 23

HIP (slow acetylators)

Question 24

AE of Lidocaine (2)?

Answer 24

• Convulsions

- Least negative inotropic

Question 25

AE of Amiodarone (3)?

Answer 25

• Pulmonary fibrosis
• Deposit in tissues/cornea
• Thyroid dysfunction (iodide)

Question 26

AE of Heparin?

Answer 26

HIT

Question 27

AE of Dabigatran (Pradaxa)?

Answer 27

Sudden withdrawal

Question 28

AE of Warfarin (2)?

Answer 28

• Drug interactions

- Quickly reduce Protein C = can cause clotting

Question 29

AE of Clopidogrel (2)?

Answer 29

• Drug interactions

- Sudden withdrawal