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Pharmacology II > EXAM #2 MOAs > Flashcards

EXAM #2 MOAs Flashcards

1
Q

CA Inhibitors MOA?

A

Inhibit CA enzyme → block H2CO3 production → less H exchange for Na = Na/water loss

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2
Q

Loops MOA (2)?

A
  • Inhibit NKCC2

- Induce kidney PGs

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3
Q

Thiazides MOA (where)?

A

Inhibit NCC IN DISTAL TUBULE

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4
Q

Aldosterone Antagonist K-Sparing MOA (3)?

A
  • Inhibit binding to mineralocorticoid receptors
  • Fewer Na channels
  • Reduce Na/K ATPase activity
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5
Q

Independent of Aldosterone K-Sparing MOA?

A
  • DIRECTLY inhibit ENaC (Aldosterone-sensitive Na channel)
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6
Q

Osmotic Diuretics MOA?

A

Increase osmotic pressure within renal tubules

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7
Q

ADH Agonist MOA?

A

Activate V2 (some V1) receptors

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8
Q

ADH Antagonist MOA?

A

Block V1 and V2 receptors

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9
Q

HF groups of drugs that INCREASE preload (2)?

A
  • Diuretics

- Venodilators

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10
Q

HF groups of drugs that INCREASE afterload?

A

Arteriodilators

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11
Q

MOA of ACE-I?

A

Inhibit ACE (ATII Converting Enzyme) = no ATII

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12
Q

MOA of ARBs?

A

Block ATII from binding to AT1 receptor = no ATII

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13
Q

MOA of Digoxin?

A

Inhibit Na-K ATPase Pump

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14
Q

MOA of Nitrites/Nitrates?

A

Vasodilate via increase NO → cGMP

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15
Q

MOA of PDE5 Inhibitors?

A

Inhibit cGMP-specific PDE5 → high cGMP → vasodilation

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16
Q

MOA of HMG-CoA Reductase Inhibitors (Statins)? Result?

A

Inhibit reductase → increase LDL receptors

- Reduce plasma LDL

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17
Q

MOA of Bile Acid-Binding Resins? Result?

A

Bind bile acids to prevent their intestinal reabsorption

- Reduce plasma LDL

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18
Q

MOA of Niacin? Result?

A

Inhibit VLDL secretion

- Reduce plasma VLDL and LDL → Increase HDL

19
Q

MOA of Fibric Acid Derivatives (Fibrates)? Result?

A

Upregulate LPL and genes involves in FA oxidation

- Reduce TGs

20
Q

MOA of Ezetimibe? Result?

A

Block intestinal absorption of cholesterol

- Slightly reduce plasma LDL

21
Q

MOA of PCSK9 Inhibitors? Result?

A

Abs inhibit PCSK9from binding to LDL receptors

- Reduce plasma LDL

22
Q

MOA of Class IA Antirrhythmics?

A

Block OPEN/ACTIVE Na channels

23
Q

MOA of Class IB Antirrhythmics?

A

Block INACTIVATED Na channels

24
Q

MOA of Class IC Antirrhythmics?

A

Block ALL Na channels

25
Q

MOA of Class II Antirrhythmics?

A

Reduce adrenergic activity on heart

26
Q

MOA of Class III Antirrhythmics?

A

Block K channels

27
Q

MOA of Class IV Antirrhythmics?

A

Block Ca channels

28
Q

MOA of Adenosine?

A

Enhance K conduction and inhibit Ca influx

- RESET HEART

29
Q

MOA of Magnesium?

A

UNKNOWN

30
Q

MOA of Potassium?

A

SLOW HEART

31
Q

MOA of Heparin (UFH)?

A

Activate Antithrombin III → affect Xa and Thrombin

32
Q

MOA of LMWH?

A

Activate Antithrombin III → affect Xa only

33
Q

MOA of Dabigatran (Pradaxa)?

A

Direct Thrombin Inhibitor

- Oral direct inhibitor of Thrombin

34
Q

MOA of Rivaroxaban (Xarelto)?

A

Direct Factor Xa Inhibitor

- Oral direct inhibitor of Factor Xa

35
Q

MOA of Apixaban (Eliquis)?

A

Direct Factor Xa Inhibitor

- Oral direct inhibitor of Factor Xa

36
Q

MOA of Warfarin?

A

Inhibit reduction of Vitamin K

37
Q

MOA of Altepase/t-PA?

A

Fibrinolytic

- Convert Plasminogen to Plasmin (dissolves clots)

38
Q

MOA of Aminocaproic Acid?

A

Antifibrinolytic

- Inhibit Plasminogen activation

39
Q

MOA of Tranexamic Acid?

A

Antifibrinolytic

- Inhibit Plasminogen activation

40
Q

MOA of Aspirin?

A

Irreversible inhibition of COX enzyme → low TXA2 (PGs)

41
Q

MOA of Clopidogrel (Plavix)?

A

Irreversibly block ADP receptor on platelets

42
Q

MOA of Ticagrelor (Brilinta)?

A

Irreversibly block ADP receptor on platelets

43
Q

MOA of Abciximab?

A

Inhibit Fibrinogen binding to GP IIb/IIIa receptor

- Ab to GP IIb/IIIa receptor

Pharmacology II (20 decks)

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