EXAM #2 MOAs

Question 1

CA Inhibitors MOA?

Answer 1

Inhibit CA enzyme → block H2CO3 production → less H exchange for Na = Na/water loss

Question 2

Loops MOA (2)?

Answer 2

• Inhibit NKCC2

- Induce kidney PGs

Question 3

Thiazides MOA (where)?

Answer 3

Inhibit NCC IN DISTAL TUBULE

Question 4

Aldosterone Antagonist K-Sparing MOA (3)?

Answer 4

• Inhibit binding to mineralocorticoid receptors
• Fewer Na channels
• Reduce Na/K ATPase activity

Question 5

Independent of Aldosterone K-Sparing MOA?

Answer 5

• DIRECTLY inhibit ENaC (Aldosterone-sensitive Na channel)

Question 6

Osmotic Diuretics MOA?

Answer 6

Increase osmotic pressure within renal tubules

Question 7

ADH Agonist MOA?

Answer 7

Activate V2 (some V1) receptors

Question 8

ADH Antagonist MOA?

Answer 8

Block V1 and V2 receptors

Question 9

HF groups of drugs that INCREASE preload (2)?

Answer 9

• Diuretics

- Venodilators

Question 10

HF groups of drugs that INCREASE afterload?

Answer 10

Arteriodilators

Question 11

MOA of ACE-I?

Answer 11

Inhibit ACE (ATII Converting Enzyme) = no ATII

Question 12

MOA of ARBs?

Answer 12

Block ATII from binding to AT1 receptor = no ATII

Question 13

MOA of Digoxin?

Answer 13

Inhibit Na-K ATPase Pump

Question 14

MOA of Nitrites/Nitrates?

Answer 14

Vasodilate via increase NO → cGMP

Question 15

MOA of PDE5 Inhibitors?

Answer 15

Inhibit cGMP-specific PDE5 → high cGMP → vasodilation

Question 16

MOA of HMG-CoA Reductase Inhibitors (Statins)? Result?

Answer 16

Inhibit reductase → increase LDL receptors

- Reduce plasma LDL

Question 17

MOA of Bile Acid-Binding Resins? Result?

Answer 17

Bind bile acids to prevent their intestinal reabsorption

- Reduce plasma LDL

Question 18

MOA of Niacin? Result?

Answer 18

Inhibit VLDL secretion

- Reduce plasma VLDL and LDL → Increase HDL

Question 19

MOA of Fibric Acid Derivatives (Fibrates)? Result?

Answer 19

Upregulate LPL and genes involves in FA oxidation

- Reduce TGs

Question 20

MOA of Ezetimibe? Result?

Answer 20

Block intestinal absorption of cholesterol

- Slightly reduce plasma LDL

Question 21

MOA of PCSK9 Inhibitors? Result?

Answer 21

Abs inhibit PCSK9from binding to LDL receptors

- Reduce plasma LDL

Question 22

MOA of Class IA Antirrhythmics?

Answer 22

Block OPEN/ACTIVE Na channels

Question 23

MOA of Class IB Antirrhythmics?

Answer 23

Block INACTIVATED Na channels

Question 24

MOA of Class IC Antirrhythmics?

Answer 24

Block ALL Na channels

Question 25

MOA of Class II Antirrhythmics?

Answer 25

Reduce adrenergic activity on heart

Question 26

MOA of Class III Antirrhythmics?

Answer 26

Block K channels

Question 27

MOA of Class IV Antirrhythmics?

Answer 27

Block Ca channels

Question 28

MOA of Adenosine?

Answer 28

Enhance K conduction and inhibit Ca influx | - RESET HEART

Question 29

MOA of Magnesium?

Answer 29

UNKNOWN

Question 30

MOA of Potassium?

Answer 30

SLOW HEART

Question 31

MOA of Heparin (UFH)?

Answer 31

Activate Antithrombin III → affect Xa and Thrombin

Question 32

MOA of LMWH?

Answer 32

Activate Antithrombin III → affect Xa only

Question 33

MOA of Dabigatran (Pradaxa)?

Answer 33

Direct Thrombin Inhibitor | - Oral direct inhibitor of Thrombin

Question 34

MOA of Rivaroxaban (Xarelto)?

Answer 34

Direct Factor Xa Inhibitor | - Oral direct inhibitor of Factor Xa

Question 35

MOA of Apixaban (Eliquis)?

Answer 35

Direct Factor Xa Inhibitor | - Oral direct inhibitor of Factor Xa

Question 36

MOA of Warfarin?

Answer 36

Inhibit reduction of Vitamin K

Question 37

MOA of Altepase/t-PA?

Answer 37

Fibrinolytic | - Convert Plasminogen to Plasmin (dissolves clots)

Question 38

MOA of Aminocaproic Acid?

Answer 38

Antifibrinolytic | - Inhibit Plasminogen activation

Question 39

MOA of Tranexamic Acid?

Answer 39

Antifibrinolytic | - Inhibit Plasminogen activation

Question 40

MOA of Aspirin?

Answer 40

Irreversible inhibition of COX enzyme → low TXA2 (PGs)

Question 41

MOA of Clopidogrel (Plavix)?

Answer 41

Irreversibly block ADP receptor on platelets

Question 42

MOA of Ticagrelor (Brilinta)?

Answer 42

Irreversibly block ADP receptor on platelets

Question 43

MOA of Abciximab?

Answer 43

Inhibit Fibrinogen binding to GP IIb/IIIa receptor | - Ab to GP IIb/IIIa receptor