Organic Arsenicals Flashcards
1
Q
Use
A
- feed additives to improve weight gain and feed efficiency
- controls GI infections in swine and poultry
2
Q
Which form is used in pigs
A
Arsanilic acid
3
Q
Which form is used in poultry
A
Roxarsone
4
Q
Source
A
- overdose or prolonged use
5
Q
Properties
A
- Phenylarsonic acid derivatives
- Pentavalent state
6
Q
Organic arsenic is more or less toxic than inorganic arsenic
A
less
7
Q
Toxicity is enhanced by
A
dehydration, water deprivation and renal insufficiency
8
Q
Toxicokinetics
A
- Small amount absorbed in GI tract
- distributed throughout body
- excreted unchanged in urine
9
Q
MOA
A
- unknown
- causes peripheral nerve demyelination
- similar to vitamin B def.
10
Q
Arsanilic acid in swine
A
- acute toxicosis in 3-5 days
- incoordination, ataxia, partial paralysis
- still have good appetite
11
Q
blindness can occur with
A
arsanilic acid
12
Q
Arsanilic CS in poultry
A
- anorexia, depression, coma and death
13
Q
Roxarsone in swine
A
- sudden onset
- hyperexcitability
- tremors, collapse, coma
death - NO blindness
14
Q
Roxarsone in poultry
A
- incoordination and ataxia
15
Q
Lesions in pigs
A
- possible erythema
- muscle atrophy (chronic)
- peripheral nerve and optic nerve degneration
