organ clinical

Question 1

psorisis vugaris

Answer 1

patchy skin lesions; accelerated keratinocyte life cycle, cells accumulate in stratum corneum, inflammation in dermal papillae, cyclic and etiology s unknown

Question 2

freckles

Answer 2

spots with extra pigment; increase in melanin without increase in malanocytes; fade in winter and darken in summer

Question 3

vitiligo

Answer 3

patches lack melanocytes; unknown etiology but associated with systemic diseases (hypo/hyperthyroidism, DM, addison’s disease, pernicious anemia, leprosy)

Question 4

moles (naevi)

Answer 4

proliferation of melanocytes

Question 5

malignant melanoma

Answer 5

melanocytes become mitotically active and invade dermis; very invasive and metastatic; surgery/chemotherapy

Question 6

effects of splenectomy

Answer 6

increased number of abnormal RBCs and larger platelet clumps;, increased rick of bacterial septicemia, liver takes up blood filtration

Question 7

infectious mononucleosis

Answer 7

caused by epstein-barr virus (EBV) on mucus and saliva

Question 8

how does mono spread

Answer 8

first replicates in nasopharyngeal epithelium and respiratory epithelium; spreads to salivay gland and lymph nodes then to liver, spleen B cells and blood; B cells infected as circulate thru oropharynx