Oral Manifestation of Systemic Disease Flashcards
Which condition is caused by excess bilirubin in the bloodstream that accumulates in the tissues, and results in a yellowish discoloration of the skin & mucosa?
Jaundice
*Gilbert syndrome has impaired metabolism in liver
What group of conditions are characterized by the deposition of an extracellular, proteinaceous substance termed amyloid?
Amyloidosis
What are the 5 main classifications of Amyloidosis?
1-Organ-limited 2-Systemic 3-Primary (Myeloma associated) 4-Secondary (Hemodialysis associated) 5-Heredofamilial
What three areas are mainly affected in the myeloma associated Primary systemic Amyloidosis?
1-Eyelid
2-Neck
3-Lips
Which classification of amyloidosis spares the heart but affects the liver, kidney and spleen?
Systemic Secondary (hemodyalisis associated) Amyloidosis
Which vitamin is essential for vision. May lead to blindness?
VItamin A (Retinol)
Which vitamin is important to maintain proper functioning of neurons. Beriberi?
Vitamin B1 (thiamin)
Which vitamin is necessary for cellular oxidation-reduction reactions. Oral alterations like angular cheilitis, glossitis?
Vitamin B2 (riboflavin)
Which vitamin acts as a coenzyme for oxidation-reduction reactions and has Pellagra triad= dermatitis, dementia, diarrhea?
Vitamin B3 (niacin)
What are the 3 components of pellagra triad?
Dermatitis
Dementia
Diarrhea
Which vitamin is a cofactor associated with enzymes that participate in amino acid synthesis?
Vitamin B6 (pyrodoxine)
Which vitamin is necessary for the proper synthesis of collagen. Scurvy?
Vitamin C (ascorbic acid)
Which vitamin is considered a hormone, necessary for calcium absorption from the gut. Rickets, Osteomalacia?
Vitamin D
Which vitamin serves as an antioxidant?
Vitamin E (a-tocopherol)
Which vitamin is necessary for proper clotting (needed in clotting factors II,VII, IX, X). Coagulopathy because of inadequate synthesis or prothrombin?
Vitamin K
Which hematologic condition has hypochromic microcytic RBC’s and has angular cheilitis and atrophic glossitis. (bald tongue)?
Iron Deficiency Anemia
*most common cause of anemia in the US and worldwide
Which syndrome is characterized by iron-deficiency anemia, glossitis, and dyshphagia?
Plummer-Vinson Syndrome
*high associated with oral and esophageal squamous cell carcinoma
The brittle spoon-shaped configuration of nails in Plummer-Vinsons syndrome are called?
Koilonychia
AKA Megaloblastic anemia, what condition has atrophic glossitis and is caused by poor absorption of cobalamin (Vit B12, Intrinsic factor)?
Pernicious Anemia
What condition results from increased production of growth hormone before closure of epiphyseal plates?
Gigantism
What condition results from increased production of growth hormone after the closure of epiphyseal plates?
Acromegaly
In terms of hypothyroidism, _____ occurs in childhood/infancy and ___ occurs in adults
Cretinism
Myxedema
What are 9 Oral manifestations of those with Type I DM?
1-Periodontal disease
2-Delayed healing
3-Increased probability of infection
4-Enlargement and erythema of the attached gingiva
5-Oral candidiasis (30%)
6-Zygomycosis (mucormycosis) – poorly controlled diabetics
7-Xerostomia (30%)
8-Diabetic sialadenosis
9-Diffuse, nontender, bilateral enlargement of the parotid glands
What condition is an inflammatory mediated condition of unknown case that has oral lesions preceding GI lesions 30% of the time?
Crohn’s Disease
What are 3 oral lesions of Crohns disease?
1-Diffuse, nodular swellings
2-“Cobblestone appearance” of the oral mucosa
3-Linear ulcerations of the buccal vestibule
