Epithelial Pathology I Flashcards
What is a benign proliferation of stratified squamous epithelium caused by Human Papillomavirus types 6 and 11?
Squamous Papilloma
The ability of virus to overcome body’s defenses and cause disease is called?
Virulence
The ability to establish infection from one person to another horizontally
Infectivity
What 3 things are on the differential diagnosis list along with Squamous Papilloma?
1-Verruca vulgaris
2-Condyloma acuminatum
3-Verruciform xanthoma
What contagious presentation is caused by HPV:2,4,6,40?
Verruca Vulgaris
*Oral lesions are more white colored. Has same differential diagnosis list as Squamous Papilloma
AKA Venereal Wart, what STD has the same differential diagnosis as Squamous Papilloma and Verruca Vulgaris?
Condyloma Acuminatum
*average size is 1-1.5 cm (much bigger than other warts)
What are the 5 main HPV types that cause Condyloma Acuminatum?
1-6* - most common 2-11* - most common 3-16 – high risk 4-18 – high risk 5-31 – high risk
Where are HPV type 16 or HPV-18 at increased risk for malignant transformation to squamous cell carcinoma?
Anogenital area
*Not the case with Oral lesions
AKA Heck’s Disease, what is caused by HPV 13 and 32 and appears in childhood?
Multifocal Epithelial Hyperplasia
A benign, localized proliferations of respiratory mucosa is called what?
Sinonasal Papillomas
*50% arise from the lateral nasal wall
What are the 3 patterns of Sinonasal Papillomas?
1-Fungiform
2-Inverted
3-Cylindrical cell
A virally-induced epithelial hyperplasia caused by DNA poxvirus typically in children is called?
Molluscum Contagiosum
What do you look for histologically in Molluscum Contagiosum?
Molluscum bodies which are also known as Henderson-Paterson bodies
A hyperplastic condition which is largely an oral disease of unknown cause (likely trauma) characterized by lipid-laden histiocytes in the epithelium is called?
Verruciform Xanthoma
*Same differential diagnosis as Squamous papilloma
Appearing as “stuck onto” the skin, what condition is common in older people and is a benign proliferation of epidermal basal cells of unknown etiology?
Seborrheic Keratosis
*no malignant potential
The form of Seborrheic Keratosis that occurs as multiple 2 mm black papules scattered around the zygomatic and periorbital region is called?
Dermatosis papulosa nigra
*30% of African Americans (Morgan Freeman). No malignant potential
Sudden appearance of numerous seborrheic keratoses with pruritus has been associated with internal malignancy and is called?
Leser-Trélat sign
Commonly called a freckle, what is a hyperpigmented macule of the skin called?
Ephelis
*More pronounced with sun exposure. Associated with painful childhood sunburns
A benign brown macule resulting from chronic UV light damage to the skin on the dorsal surfaces with well-demarcated irregular borders is likely?
Actinic Lentigo
*Related to Sun exposure. No change in color intensity with UV light exposure (unlike Ephelis)
A benign cutaneous melanocytic hyperplasia that is indistinguishable from the nonelevated melanocytic nevus is called?
Lentigo Simplex
*smaller than 5 mm with uniform brown color that does not change with sunlight
An acquired, symmetrical, hormonally-driven hyperpigmentation of the sun-exposed skin of the face is called?
Melasma
*associated with pregnancy
What is the oral counterpart to ephelis called?
Oral melanotic Macule
*Most common site = vermilion zone of the lower lip (LABIAL melanotic Macule)
An acquired pigmentation of the oral mucosa likely due to trauma almost exclusively in African Americans on the buccal mucosa that rapidly increases in size is called?
Oral Melanoacanthoma
The most commonly recognized nevus that is AKA mole is an increased number of cells (melanocytes) resulting in a mass called what?
Acquired Melanocytic Nevus
Though intraoral melanocytic nevi are uncommon, where do they typically appear in the oral cavity?
Palate
AKA Birthmark, what feature is similar to an acquired melanocytic nevus though they are usually larger?
Congenital Melanocytic Nevus
*Large type may present with Hypertrichosis (Hairy)
A melanocytic nevus with a surrounding pale hypo pigmented border is called?
Halo Nevus
A benign proliferation of dermal (or intramucosal) melanocytes that appear blue due to the tyndall effect are called?
Blue Nevus
*Common (1 cm usually on palate) and cellular (usually on buttock) types
