Opiates

Question 1

What opioid does not produce bradycardia

Answer 1

Meperidine

Question 2

Which opioids are associated with histamine release?

Answer 2

Morphine, meperidine and codeine

Question 3

Which opioids may be associated with seizure activity in patients with renal failure?

Answer 3

Hydromorphone and meperidine are associated with seizure activity in patients with renal failure.

Question 4

is a codeine analog that acts as a m-, d-, and k-receptor agonist and a reuptake inhibitor of norepinephrine and serotonin.

Answer 4

Tramadol

Question 5

Is and opioid that may induce tachycardia

Answer 5

Meperidine

Question 6

What drug should not be combined with meperidine and may lead to serotonin toxicity, hyperthermia, and death.

Answer 6

Meperidine

Question 7

Which opioid lipid solubility diffuses more across spinal membranes?

Answer 7

Lipophlic
However, they also diffuse across vascular membranes more readily, typically resulting in increased serum concentrations and a shorter duration of action.

Hydrophilic opioids achieve greater cephalo-caudal spread when administered into the epidural or subarachnoid space. They attain broader analgesic coverage than lipophilic opioids but may result in delayed respiratory depression following cephalad
spread to the brainstem.

Question 8

This is an opioid agonist that consists of lipid-based particles with internal morphine vesicles. It is approved only for single-dose epidural use and may provide up to
48 hours of analgesia.

Answer 8

DepoDur (DepoFoam)

DepoDur may not be coadministered with local anesthetics because of the risk of accelerated morphine release.