Intravenous Anesthesia Flashcards
2 IV anesthetics with analgesic property
- Ketamine
2. Dexmedetomidine
IV anesthetic with less sedation
Methohexital
IV anesthetic with less cardiovascular depression than the barbiturates and propofol.
Etomidate
MOA of IV anesthetics
Inhibition of GABA
Principal inhibitory neurotransmitter of the CNS
GABA
Most IV anesthetics are excreted primarily via?
Hepatic metabolism
What factor enhances the cardiodepressant response to propofol and a reduced dosage is required in studies of the patients.
Age
Mechanism of the anti-emetic property of propofol.
- Antidopaminergic activity
- Depressant effect on the chemoreceptor trigger zone and vagal nuclei
- Decreased release of glutamate and aspartate in the olfactory cortex
- Reduction of serotonin concentrations in the area postrema
Induction agent of choice in malignant hyperthermia-susceptible patients
Propofol
Characterized by cardiac failure, rhabdomyolysis, metabolic acidosis, and renal failure and is often fatal.
Hyperkalemia, hypertriglyceridemia, and hepatomegaly are also key features.
Propofol infusion syndrome
High doses and long-term use of propofol (>4 mg/kg/hr for >24 hours
Drug that inhibit the oxidative metabolism of diazepam include?
Cimetidine
Benzodiazepines that are insoluble in water? (2)
Diazepam
Lorazepam
What content in benzodiazepines that causes pain on injection?
Propylene glycol
A carboxylated imidazole-containing anesthetic compound (R-1-ethyl-1-[a-methylbenzyl] imidazole-5- carboxylate) that is structurally unrelated to any other IV anesthetic.
Etomidate
Etomidate inhibits the activity of ________, an enzyme necessary for the synthesis of cortisol, aldosterone, 17-hydroxyprogesterone, and corticosterone.
11-b-hydroxylase
