ophtho 1/24/17

Question 1

diabetics how many more times more likely to go blind than gen pop?

how many newly diagnosed diabtics will show signs of retinopathy on exam

Answer 1

20x more likely

1/5 (20%)

Question 2

pathogenesis of diabetic retinopathy

Answer 2

-Glycosylaiton of vessel walls throughout body but particularly microvasculature eg capillaries of retina and glomeruli, collagen Denaturation, wall Thickening, capillary wall Breakdown, Microaneurysms, Dot-blot hemorrhages, Cotton-wool spots from ischemia/infarction of superficial retinal nerve fibers, beading of retinal veins, other vascular anomalies
(NON-PROLIFERATIVE Diabeitc Retinopathy) macular edema when severe (most common cause of blindness in diabetics), yellow “hard exudate” lipid deposits left behind like bathtub ring
-vessel occlusion