gen surg Flashcards
treat malignant hyperthermia
o2
dantrolene
cold ivf
dantroline
moa
and use in surgical context
uncouples excitation contraction by decreasing intracellular calcium by blocking ca release from sarcoplasmic reticulum
tx malignant hyperthermia
which anesthetics cause malignant hyperthermia
volatile ones
inhaled halothane, fluranes
succinylcholine
mechanism of malignant hyperthermia
variant dihydropyridine or ryanodine ca receptors cause unregulated release of ca when certain volatile anesthetics bind (halothane, fluranes, succinylcholine) – sustained muscle contraction and hypercatabolic state, rhabdo when atp depleted, hyperthermia when heat generation outweighs dissipation
pyridostigmine moa
and use in tx of postop complication
blocks AchE
tx Olgilvie Syndrome – ileus of colon, commonly post-op in elderly
(more Ach, more ANS, more GI motility)
does hepatitis cause direct or indirect hyperbilirubinemia
mixed, intrahepatic
is genetic hyperbilirubinemia typically direct or indirect?
mixed, intrahepatic
signs and symptoms of choledocolithiasis vs biliary stricture/cancer
choledocolithiasis:
-fever, leukocytosis, +murphy, pain
stricture/cancer -afebrile, normal WBC, -murphy, wight loss clay colored stool painless jaundice distended non-painful gallbladder
how to diagnose choledocolithiasis vs biliary stricture/cancer
RUQ US
MRCP
for both
treat choledocholithiasis
ECRP (preferred)
cholecystectomy
treat biliary stricture/cancer
depending on specific disease:
EUS + bx (pancreatic cancer) – whipple
ERCP + bx (cholangiocarcinoma) – resection
stenting (stricture not PSC (don’t stent PSC because need transplant…)
resection (ampulla of vater)
s&s of obstructive jaundice not choledocholithiasis
wight loss
clay colored stool
painless jaundice
distended non-painful gallbladder
signs of ampulla of vater as cause of painless obstructive jaundice
dx
tx
+FOBT
-colonoscopy
ERCP + bx
resection
sings of pancreatic cancer as cause of painless obstructive jaundice
migratory thrombophlebitis
EUS + bx
whipple
signs of cholangeocarcinoma as cause of painless obstructive jaundice
dx
tx
PSC (beads on string)
ERCP + bx
resection
how to treat biliary stricture
stent
unless PSC.. will need… transplant..?
simple definition of thrombophlebitis
venous clots associated w inflammation and pain
painless obstructive jaundice and migrating thrombophlebitis suggests
pancreatic cancer
dx EUS + bx
tx whipple
painless obstructive jaundice
+FOBT
-colonoscopy
suggests…
ampulla of vater issue..
painless obstructive jaundice and PSC suggests…
cholangeocarcinoma
dx ERCP + bx
tx resection
2 biggest cardiovascular CIs to surgery
HFrEF v35% = moratility risk 75%
MI v 6 mos (40% mort at 3, 6% mort at 6)
goldman index
what is it
measure of cardiovascular CIs to surgery
most important factors are
HFrEFv35%
MIv6mos
CV preop screen
ECG (CI if MIv6mos)
echo (CI if HFrEFv35% - 75% mort)
stress test / left heart cath (CI if MIv6mos)
surgical mortality risk if MI within
3 mos
6 mos
40% at 3
6% at 6
treat MI
stent (preferred)
CABG
treat CHF
BB
ACEI
diuretics
pulm CIs to surgery
smoker
COPD/asthma
ILD
preop pulm screen
PFTs
ABG
(for COPD, asthma, ILD… ^CO2, vO2)
preop liver screen
mortality risk
management
MELD Childs-Pugh important factors include: albumin v pt/ptt ^ TBili ^ ascites encephalopathy --any 1 = 40% mort, all = 100% mort --liver transplant
why is nutrition screened preop?
affects healing ability
preop nutrition screen
workup
management
20% weight loss in 3 mos
albumin v 3
skin anergy (not enough proteins for Igs for allergy)
prealbumin & CRP – other proteins body makes, to diff malnutrition from liver failure
PO nutrition preferred to parenteral IV
for 10 days preferred to 5 days
tf
prealbumin is made by the liver and turns into albumin
f
it comes before albumin when run on gel electrophoresis
it is another protein made by the body, screened eg to diff malnutrition from liver failure
preop metabolic screen
management
blood glucose
for DKA (glucose ^^ in DKA)
IVF and IV insulin
preop screen consists of these tests for these diseases of 5 organs/systems
ECG, echo, stress test/LHC – HFrEF, MI
PFTs, ABG – COPD, asthma, ILD
alb, pt/ptt, tbili, ascites, encephalopathy - liver failure
20% weight loss 3 mos, alb, skin anergy, prealbumin, crp – malnutrition
blood glucose – dka
another name for prealbumin
transthyretin
called prealbumin because runs just ahead of albumin on gel electrophoresis, not a synthetic precursor to albumin, not synthesized by liver
overview of post-op fever and causes days 0-14
0 intraop wonder drugs malignant hyperthermia postop day of surg bacteremia 1 wind atelectasis 2 wind PNA 3 water UTI 5 water DVT/PE 7 wound cellulitis 10-14 wound abscess
intraop fever
dx
tx
ppx
clinical dx
malignant hyperthermia
O2; dantrolene, cool IVF
get family history
postop fever day of surgery
dx
tx
ppx
blood cx
bacteremia
broad abx eg vanc piptazo
sterile precautions
postop fever day 1
dx
tx
ppx
CXR
atelectasis
tx & ppx incentive spirometry, get out of bed
postop fever day 2
dx
tx
ppx
CXR
PNA
broad abx (HAP… vanc piptazo)
incentive spirometry, out of bed
postop fever day 3
dx
tx
ppx
UA Ucx
UTI
abx
remove foley ASAP
postop fever day 5
dx
tx
ppx
US bilateral LE
DVT/PE
heparin - warfarin
LMWH (can start postop), out of bed
postop fever day 7
dx
tx
ppx
clinical, may be erythematous, not closed well
US negative for abscess, CT positive for cellulitis
Abx
sterile precautions and hygiene
postop fever day 10-14
dx
tx
ppx
US or CT shows abscess
abscess
abx; I&D
sterile precautions and hygiene
7 broad classes of postop complications to look out for
fever AMS chest pain abdominal distension renal failure (v output) wound non-closure fistula
ddx postop AMS and how to treat
# DTs - 24-48hr hypot, tachyc, sweats; 48-72 hr tremors -- benzos # hypoxemia: PE-anticoag; HAP-abx; ARDS-PEEP # sundowning (elderly) - anipsychotics # elytes - replete Na, Ca etc
brief definition of sundowning
tx
dementia-related agitation, confusion, hyperactivity building in late afternoon and evening
-antipsychotics
ddx postop chest pain
workup
tx
# MI - ECG trops - PCI heparin NOT tPA POSTOP # PE - US CT sprial - heparin--warfarin
ddx postop dec urinary output
workup
tx
urge - bladder scan - obstruction - unkink foley, irrigate, in&out cath
no urge = renal failure - 500cc fluid bolus
inc output after bolus - prerenal - IVF
still no output after bolus - intrarenal - int med
ddx postop abdominal distension
workup
tx
no stool no flatus # day 1,2 - ileus / ogilvie - KUB - IVF, K+, out of bed for ileus -- rectal tube, stigmine, colonoscopy for ogilvie (colon ileus in elderly) # day 5 - obstruction - KUB - SBO vs LBO - NG tube npo ivf for sbo... surg, lbo is surg
SBO vs LBO appearance on KUB
SBO dilated proximal sb compressed distally
LBO dilated proximal lb compressed distally but normal sb because ileocecal valve prevents further backup
wound dehiscence is a failure of what layer of a wound
the fascia
wound dehiscence
s&s
dx
tx
serosanguinous/salmon colored drainage herniation clinical dx binders avoid straining elective reoperation
difference betwen dehiscence and evisceration
dehiscence - failure of fascia
evisceration - failure of whole wound
wound evisceration
dx
tx
clinical dx - intestines are spilling out
apply warm saline dressing
emergent surgery
NEVER PUT SPILLAGE BACK IN w/o surgical setting
postop fistula
ddx
tx
FETID
foreign body, epithelialization, tumor, inflammation/irradiation, distal obstruction
resect fistula
divert into ostomy while treating cause if necessary
most common complication of thyroidectomy
and assoc sx
hypoParathyroidism/hypocalcemia
from asymptomatic incidental lab finding
to non-specific fatigue anxiety depression
to severe tetany seizures qt prolongation (qtc v460 normal)
normal QTc
v460
what electrolyte abnormality is seen with persistent hypothyroidism post-thyroidectomy
hyponatremia
tf
qt prolongation a result of hypothyroidism post thyroidectomy
f
not a result of hypothyroidism/hyponatremia
a result of hypoParathyroidism hypoCalcemia
how does vitamin D toxicity affect ekg
qt shortening from hypercalcemia