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Surgery > neurosurg 01/22/17 > Flashcards

neurosurg 01/22/17 Flashcards

1
Q 
subarachnoid hemorrhage
path
pres
dx
tx
A

-aneurysm leaks or bleeds (usually w some activity that causes berry aneurysm to rupture)
-thunderclap headache (sudden and suddenly maximally intense, “worst headache of life”)
hx of sentinal bleed (if pt awake to tell)… treated symptomatically, went away
neck stiffness
headache - fnd - coma
-non-con head ct (for blood in subarachnoid space, cisterns, sulci, maybe ventricles… not parenchyma)
maybe lp for xanthochromia if noncon head ct neg but still want to ro subarachnoid
-early tx (v48hrs) - dec Bleeding by dec bp v140/90 (bb’s, ccb’s) coil or clip aneurysm, dec Hydrocephalus w serial lp’s or vp shunt… more likely to clip and shunt if opening head w craniotomy to dec pressure when pt really in bad shape… otherwise if no craniotomy prob coil and serial lp’s), try to dec ICP w mannitol or hypertonic saline elevating head of bed and hyperventilation to avoid craniotomy, Seizure ppx (any first line, eg levitiracetam keppra)
-late tx (5-7days) - ppx Vasospasm w ccb’s (nimodipine), tx breakthrough vasospasm by inc bp w vasopressors (not bleeding anymore so strat diff from early tx)

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2
Q

what info does a non-con brain ct give you

A

blood or no blood
bleed
eg in setting of stroke, subarachnoid hemorrhage, intraparenchymal hemorrhage, epi, subdural hematoma…)

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3
Q

lens shaped dural hematoma is…

A

epidural

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4
Q

crescent shaped dural hematoma is…

A

subdural

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5
Q

diagnosed subarachnoid hemorrhage by noncon head ct

next diagnostic step is…

A

angiography (mr or ct preferred to.. the one where poke skin… unless endovascular maneuvar to treat pending…)

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6
Q

want to rule out subarachnoid hemorrhage despite negative noncon head ct (eg w milder sx.. like bad headache w hx of sentinal bleed… vs massive fnd’s w negative ct definitely not subarachnoid hemorrhage)…
next diagnostic step…

A 
lumbar puncture
for xanthochromia (yellow tinged csf from old blood)
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7
Q

how to diff subarachnoid hemorrhage from traumatic tap by lp

A

csf blood will not clear by tube 4 like traumatic tap will

traumatic tap (some iatrogenic bleeding) may show blood in tube 1 but should be absent by tube 4…

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8
Q 
intraparenchymal hemorrhage
path
pres
dx
tx
A

-almost always in setting of htn
-fnd ha n/v
ams coma if rapid progressing and severe
-noncon head ct scan
-dec ICP w mannitol or hypertonic saline elevating head of bed and hyperventilation, craniotomy and evacuation of bleed if necessary
-f/u w ct scans to check if hematoma expanding, will need to evacuate if so (can cross midline, uncal herniation - cn III occ motor palsy psns fixed pupillary dilation first before motor down and out palsy… potential brainstem compression respiratory depression and death…)

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9
Q

describe subarachnoid hemorrhage vs prior sentinel bleed with regard to medication response

A

subarachnoid - not responsive to morphine

sentinel bleed - able to push through with acetaminophen and ibuprofen

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10
Q

what type of headaches does high flow oxygen treat

A

cluster headaches

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11
Q

when is cerebral ischemia from vasospasm a risk after subarachnoid hemorrhage

A

5 days to 6 weeks

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12
Q

bleeding in brain w fnd’s… next step

A

immediate surgical evacuation

for med student level… some intricacies to not evacuating

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13
Q

what kind of brain bleed can be treated w endovascular repair

A

subarachnoid hemorrhage

others cannot

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14
Q

when is lumbar puncture the answer in the setting of a brain bleed

A

ONLY to ro subarachnoid negative on CT

NEVER remove csf from a system w compressive symptoms (inc ICP can cause herniation and death)

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15
Q

“walk, talk, die” syndrome in setting of brain bleed corresponds to what dx

A 
epidural hematoma (w lucid interval)
(brisk arterial bleed most often middle meningeal, midline shift and herniation)
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16
Q

pt on coumadin for afib presents w small intraparenchymal hemorrhage on head ct
next step…

A

ffp
stop the brain bleed, ffp is fastest
(unless already signs of herniation, then choose craniotomy)

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17
Q

fall plus progressive dementia

think…

A

chronic subacute subdural hematoma

torn bridging veins, elderly

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18
Q

2 presentations of subdural hematomas

A

super trauma plus loc where pt does not wake up - acute
(mva, shaken baby, big fall)
mild trauma plus no loc w progressive cognitive decline - chronic subacute
(alcoholics and elderly - bridging veins stretched from cortical atrophy easier to shear w minor trauma)

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19
Q

locked in syndrome
define
which artery thrombosed
what does it look like on ct

A

looks like persistent vegetative state but fully awake aware and conscious
basilar artery
ct is normal

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20
Q

think a guy w sudden fnd’s is having a stroke
next step?
nexts?

A

head ct - to rule out intracranial hemorrhage

must know if bleed or not bleed or else mismanagement can be fatal

then mri to confirm stroke
carotid us to assess for stenotic lesion
2D echo and ecg telemetry

tPA if no bleed, asa for secondary ppx of stroke

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21
Q

focal neurologic deficit of short duration

next dx test to get

A

head ct
(will be first step whether infection, mass, bleed, ischemic stroke)

must diff bleed from no bleed before trying to treat

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22
Q

basilar skull fracture

presentation

A

racoon eyes
ecchymosis below/behind ear
clear otorrhea/rhinorrea (csf out ears or nose)

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23
Q

tf

clear otorrhea/rhinorrhea in setting of trauma is boogers

A

f

think csf

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24
Q

blood vessel assoc w epidural hematoma

A

middle meningeal artery

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25
Q

epidural hematoma
pres
dx
tx

A

super trauma (baseball bat, ski accident)
loc - lucid interval - die (walk talk die syndrome)
-ct scan - lens shaped hematoma
-craniotomy to evacuate hematoma

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26
Q

tf

anyone w head trauma significant enough for loc deserves a ct scan

A

t

ro bleed

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27
Q

tf

decreasing ICP likely to affect prognosis of acute subdural hematoma

A

f
do hyperventilate, elevate head of bed to 30deg, give mannitol or hypertonic saline to dec icp
but if pt dying from subdural, prob from parenchymal damage not icp

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28
Q

acute subdural hematoma
pres
dx
tx

A

young pt (shaken baby, teen w superman syndrome mva or ski)
massive trauma, loc, death
ct scan noncon - crescent shaped hematoma
dec ICP - hyperventilate, elevate head of bed to 30deg, give mannitol or hypertonic saline
but not likely to impact prognosis - if pt dying from subdural, prob from parenchymal damage not icp

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29
Q

concussion
pres
dx
tx

A

sports trauma - loc - retrograde amnesia (can’t remember the play and some leading up to it..)

  • noncon ct scan (mri will prob show swelling, but not necessary, see tx)
  • GCS^15 and neg ct - can go home under obs and return if any neuro change (can’t arouse, n/v, fnd, sz, etc…)
  • GCSv15 or pos ct - need to be admitted because need for neurosurg possible…
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30
Q

diffuse axonal injury

pres

A

Angular trauma (spinning etc)
loc - no recovery - coma
noncon ct - gray-white blurring
tx - pray, can try to dec ICP but edema not going to kill them, parenchymal injury will

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31
Q

motor nerve to biceps brachii

A

musculocutaneous nerve

C5 C6

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32
Q

motor nerve to brachoradialis

A

radial nerve

C 5 6 7 8 T1

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33
Q

motor nerve to triceps brachii

A

radial nerve
C 5 6 7 8 T1
(long head may be innervated by axillary nerve C5 C6

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34
Q

motor innervation of quadriceps muscle

A

femoral nerve

L2 3 4

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35
Q

motor innervation of gastrocs and soleus

A 
tibial nerve (branch of sciatic)
L45 S123
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36
Q

Deep tendon reflexes, main spinal nerve roots involved

A 
biceps C56
brachioradialis C6
triceps C7
patellar L4
achilles S1
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37
Q

never dx cancer wo…

A

tissue

but can sometimes guess pretty well based on risks hx imaging etc

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38
Q

% brain cancer that are mets

and which ones

A

70%

lung breast gi
then melanoma…

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39
Q

tf

brain cancer metastasizes

A

f

causes sc and death before it mets usually

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40
Q

describe cancer mets to brain on imaging

A

multiple lesions at grey-white junction

where vasculature catches cancer and other emboli

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41
Q

presentation of brain cancer

A

fnd’s
seizure
headache (eg if compression or mass effect… no sensation in brain)
n/v

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42
Q

what about headaches and nausea and vomiting become extra concerning for brain cancer

A

headache worse lying down at night

progression of nausea an vomiting

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43
Q

GCS

A

glasgow coma scale 3-15
eye response
-open spontaneously 4, to verbal, to pain, none 1
verbal response
-oriented 5, disoriented, inappropriate, incomprehensible sounds, none 1
motor response
-obeys verbal 6, localizes pain, withdraws, decorticate (flex) above red nuc, decerebrate ext below red nuc, none 1

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44
Q

“crab of death” on head ct

A

non con blood in csf space, fissures

subarachnoid hemorrhage

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45
Q

difference between shunt and drain

A

shunt into another part of body

drain/ostomy out of body

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46
Q

opisthion

basion

A

midpoint posterior foramen magnum opisthion

midoint anterior foramen magnum basion

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47
Q

define chiari malformations

A

anatomic anomalies of cerebellum, brainstem, craniocervical junction… w downward displacement of cerebellum maybe w lower medulla into spinal canal

  • I cerebellar tonsils abnorm shape below foramen magnum
  • II (arnold-chiari) vermis and tonsils down, beaked midbrain, spinal myelomeningocele
  • III (rare) small posterior fossa w high cervical or occipital omphalociele, w cerebellar stuffs into omphalocele, brainstem down into spinal canal
  • IV (obsolete) cerebellar hypoplasia unrelated to other chiari malformations
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48
Q

micro vs macro pituitary adenoma

A

v^1cm 10mm

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49
Q

name front middle and back of sella turcica

A

tuberculum sella
sella turcica
dorsum sella

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50
Q

innervation of dura

A

trigeminal V supretentorial

vagus X infratentorial

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51
Q

think cancer in brain? best test to get

A

MRI w contrast best
(no contrast w ckd.. so noncon MRI next next best…)

then next CT w con if MRI ci
then CT w/o con last resort

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52
Q

tx primary brain cancer

A

resection radiation chemo
steroids are palliative
sz ppx (lamotrigine, phenytoin, levetiracetam … general antieplieptics..)

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53
Q

prognosis of primary brain canceer

A

not good

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54
Q

prolactinoma flyby
sx
dx

A
  • bitemporal hemianopsia, large lesions in men
  • amennorrhea, galactorrhea, small lesions in women
  • pregnancy test, tsh, prl – mri when prolactin elevated
  • dopamine agonists
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55
Q

acromegaly flyby
sx
dx

A

-kids - gigantism
-adults - heart visceral organs face and hands grow don’t fit right, teeth separate, etc
(the stuff that can grow does grow)
-insulin-like gf, glucose suppression test fails to suppress – get brain mri

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56
Q

craniopharyngioma
pres
dx
tx

A
  • asyx tumor in kids… may get short stature if compressing other ant pit hormones…(functional pan-hypopituitarism, but not actually
  • calcification of sella on ct or xr
  • resect
57
Q

most common pituitary tumors to know

A

prolactinoma (male vs female)
acromegaly (kids vs adults)
craniopharyngioma (kids)

58
Q

age predilection anterior fossa vs posterior fossa brain tumors

A

Ant Adults

Post Peds

59
Q

tumors to know in posterior skull fossa

A

medulloblastoma

ependymoma

60
Q 
posterior fossa brain tumor
2 ddx
pres
distinctions
tx
A
  • medulloblastoma
    ependymoma. ..
  • ICHTN - n/v kid worse in morning, better when curls up into a ball…
  • medulloblastoma highly malignant seeds arachnoid get distal lesions – resect AND radiation
  • ependymoma from 4th ventricle, obstructive hydrocephalus (better in fetal position.. repositions tumor for ventricular outflow and decreases ICP )
    • resection usually enough w/o chemo.. usually no distal lesions
61
Q

anterior fossa brain tumor

2 ddx

A

-meningioma - dural, fnd from mass effect – ct scan (calcified/connected to dura) – resection is curative
(the good one to have)

glioblastoma - parenchyma, highly mitotic, necrotic, eats brain… ring-enhancing lesion or bat’s wing deformity (the Only brain cancer that crosses midline, eats way through… not just mass effect) – dismal prognosis… try to resect

62
Q

astrocytoma fly/by meded

A

(adult cancer)
basically glioblastoma but prognosis less dismal
(glioblastoma - parenchyma, highly mitotic, necrotic, eats brain… ring-enhancing lesion or bat’s wing deformity (the Only brain cancer that crosses midline, eats way through… not just mass effect) – dismal prognosis… try to resect)

63
Q

schwannoma
pres
tx

A 
(adult cancer)
n/v
hearing loss
vertigo
tinnitis
-resect
64
Q 
early morning headaches progressing
projectile vomiting
papilledema
think...
order...
A 
brain tumor (complicated headaches lead away from pseudotumor eg if this were a young female)
get MRI
65
Q

what part of head do CTs have a tough time visualizing

A

posterior fossa

66
Q

first test for psudotumor ceribri

A

ct

67
Q

ddx 32 yo f inc

A

pseudotumor
vs
brain tumor

68
Q

diagnose normal pressure hydrocephalus

A

lp - elevated opening pressure confirms ICHTN, releif of sx confirms dx

69
Q

reduce ICP for symptomatic relief while awaiting neurosurgical bx and resection of brain tumor

A

dexamethasone (choice med)

serial lp’s or vp shunt can also be used

70
Q

benign intracranial htn

A

= idiopathic intracranial htn
=psudotumor cerebri

NOT equal to normal pressure hydrocephalus

71
Q

simply define normal pressure hydrocephalus

A

pathologically enlarged ventricular size with normal opening pressures on lumbar puncture

72
Q

sudden onset coma and hypotension following headache w bitemporal hemianopsia in woman who has had headaches, worsening hemianopsia, and amenorrhea suggests…

A

pituitary apoplexy
(prob pit adenoma (prolactinoma) given amenorrhea… small tumor in females… microadenoma because symptomatic galactorrhea amenorrhea… sx ignored, grew pressed on optic chiasm… outgrew blood supply and died, hemorrhaged, comprised all pituitary – panhypopituitarism of sudden onset, ACTH and TSH lost so Cortisol and T4 lost – no catecholamines no blood pressure vessels can’t be made to constrict
so t w IV DEXamethasone - corticosteroid effect to regain bp (not or reducing ICP here)

73
Q

tx prolactinoma

A

dopamine agonists
radiation therapy
resection

74
Q

tx pituitary apoplexy

A

IV DEXamethasone - corticosteroid effect to regain bp (not or reducing ICP here)

(e.g prob pit adenoma (prolactinoma), amenorrhea… small tumor in females… microadenoma because symptomatic galactorrhea amenorrhea… sx ignored, grew pressed on optic chiasm… outgrew blood supply and died, hemorrhaged, comprised all pituitary – panhypopituitarism of sudden onset, ACTH and TSH lost so Cortisol and T4 lost – no catecholamines no blood pressure vessels can’t be made to constrict

75
Q

nasty looking necrotic tumor w ring enhancement that crosses midline

best guess at dx

A

glioblastoma multiforme most likely

but dx w tissue bx

76
Q

brain mri in kid w stunted growth think…

A

craniopharyngioma… look at sella/pit

(asyx tumor in kids… may get short stature if compressing other ant pit hormones…(functional pan-hypopituitarism, but not actually

  • calcification of sella on ct or xr
  • resect)
77
Q

meningiomas are cured by..

A

resection

78
Q

tf

meningiomais a brain tumor

A

F

an intracranial tumor but not a brain tumor

79
Q

meningioma will present w

A

headaches and seizure

80
Q

age of menintioma pt

A

18-30 adult usually

81
Q

tf

all intracranial caners best dxd w mri

A

f

eg meningioma dense like bone, ct best

82
Q

when are iv abx indicated in a ring-enhancing lesion w fnd’s or seizure

A

when febrile

thinking abscess

83
Q

primary brain tumors of kids

A

most commonly

  • pituitary craniopharyngioma
  • ependymoma
  • medulloblastoma
84
Q

tf

craniopharyngioma generally presents w headache

A

f

tweenager w limited growth and potentially low prl and tsh

85
Q

calcified pituitary mass =

A

craniopharyngioma

86
Q

cushing reflex
define
pathogenesis
tx

A

-htn and tachyc from inc ICP from brain mass

cause rogressively worsening fnds inpt

87
Q

what are plain films of the head useful for…

A

cranial suture anatomy
paranasal and frontal sinuses
sella turcica
(eg for preop planning)

88
Q

distinguishing characteristic of cervical vertebrae

A

transverse foramen
(foramen transversarium)
-for passage of vertebral arteries

89
Q

types of cervical vertebrae

A

atlas c1
axis c2
subaxial (typical vertebrae)

90
Q

x ray use for c-spine

A

trauma

degeneratie diseaes

91
Q

the most frequently useful plain film view of spine

A

cross-table lateral view

-2/3’s spinal pathology can be detected in this view

92
Q

check to make sure plain film caught the whole c-spine

A

look for cervical-thoracic junction (c7-t1)

93
Q

how many cervical vertebrae

A

7 (8 cervical spinal roots however)

94
Q

swimmer’s view xr

  • what is it
  • why do
A

one arm raised above the head
-to better visualize the lower c-spine in pt w shoulders that obscure cervico-thoracic junction on cross-table lateral view

95
Q

special xr views of c-spine

-uses

A
  • swimmer’s (to see c-t junction if humerus obscures on cross-table lat)
  • open mouth odontoid view (can be done w pt supine)
  • flex-ex (flexion-extension, for pt w neck pain but no bony abnorm on standard views, or degenerative dz, intervertebral foramena if root compression suspected)
96
Q

tf

open mouth odontoid xr can be taken w pt supine

A

t

97
Q

distinguishing characteristic of thoracic vertebrae

A

costal facets

98
Q

use of thoracic spine plain film

A

trauma
-fx, subluxation, loss of vertebral body height
(AP and cross table lat can be done w pt supine)

99
Q

distinguishing features of lumbar vertebrae

A

LACK costal facets (thoracic) and transverse foramena (cervical)

  • small transverse processes
  • large spinous processes
100
Q

how many sacral vertebra

A

5

fused

101
Q

sacrum articulates with

A

L5

ilia

102
Q

useful views of lumbosacral spine

A

ap - trauma, fx/sublux (can be done supine on backboard)
lat
flex-ex - ligamentous injury - spondylolisthesis
oblique - spondylolysis (pars interarticularis fx or congenital defect)

103
Q

use of CT in neurosurg

A

acute lesions

  • intracranial hemorrhage, fx, edema, mass lesions (mass effect), hydrocephalus, infarction
  • –or per meded “bleed or no bleed”
104
Q

use of angioplasty in neurosurg

A

diangostic and therapeutic uses

  • coils, balloons, eg for cerebral aneurysms, and w surgery and radiosurgery of avm’s
  • superselective intra-arterial papaverine or balloon angioplasty eg for cerebral vasospasm after subarachnoid hemorrhage
105
Q

appearance on MRI depends on

A

proton content and spin properties…

106
Q

3 MRI settings important in brain and spine

A

T1 T2 proton density

107
Q

functional definition of gadolinium

A

non-iodinated contrast material that is hyperintense on T1 MRI

108
Q

use of contrast MRI

A

impaired bbb

  • gadolinium contrast is hyperintense on T1 MRI and does not cross normal bbb
  • so tumor, infection, vascular anaomaly, normal pituitary are permeable to contrast agents and show preferential enhancement
109
Q

leading cause of death in children and young adults in us

A

trauma

head injury is cause in 50% of deadly trauma

110
Q

tf

fracture corresponds to severity of head injury

A

f

brain can be very injured w/o skull fx

111
Q

3 types of skull fxs

A
  • linear - nondisplaced
  • depressed - displacement of skull cortexes (diploic tables) in relation to one another
  • diastic - along suture line - primarily in children
112
Q

define diploe

A

the red bone marrow between cortical ‘tables’ of the skull

113
Q

define ‘growing skull fx’

A

aka leptomeningeal cyst

skull fx w tear of dura in kids - outpouching of brain tissue and meninges

114
Q

define leptomeningeal cyst

A

“growing skull fx”

skull fx w tear of dura in kids - outpouching of brain tissue and meninges

115
Q

pathogenesis of pneumocephalus after skull base fx

A

dural tear communicates w paranasal sinuses or mastoid air cells - Very low density (black) areas near paranasal sinuses
-may get csf rhinorrhea or otorrhea

116
Q

feared complication of temporal bone fx

A

CN VII facial nerve palsy - complete ipsilateral facial paralysis

117
Q

tf

facial nerve palsy causes complete ipsilateral facial paralysis

A

t
distal…after some nucleus… facial nerve lesion causes complete ipsi paralysis…. prior to that nucleus, lesion will only cause ipsilateral lower quadrant paralysis as opposite facial nerve cross-covers upper quadrant

118
Q

epidural hematoma

  • between what layers
  • what blood vessels
  • what % of head trauma pts
  • what % of fatalities from head trauma
A

skull and dura
middle meningeal artery or dural venous sinus
1-4% pts w head trauma
10% of fatalities from head trauma

119
Q

another word for “lentiform” hematoma

A

biconvex

120
Q

which hematoma does not cross suture lines usually

A

epidural

121
Q

subdural hematoma

  • between what layers
  • what blood vessels
  • what mechanism
  • what % of head injuries
A

dura and arachnoid maters
bridging veins
change in head velocity
10-20% of head injuries will have

122
Q

chronic subdural hematoma
pres
ct appearance

A

elderly (brain atrophy, bridging veins stretched, easier to break w less trauma, minor trauma, or no apparent trauma at all)

  • usually hypodense
  • can be heterogenous if rebleeding (repeat trauma elderly) or neovascular membrane formation
123
Q

acute subdural hematoma on ct

A

hyperdense
sometimes iso or hypodense due to csf or unclotted blood mixing w clotted blood
crescent shaped

isodense to brain after weeks and clot ages over

124
Q

subarachnoid hemorrhage

  • between what layers
  • present in what % of head trauma cases
  • CT pattern
A

arachnoid and pia
most moderate to severe head trauma
follows suci and/or csf cisterns at base of brain

125
Q

primary brain injuries seen on imaging include…

A

cerebral contusion
diffuse axonal injury
brainstem (duret) hemorrhage

126
Q

duret hemorrhage

A

brainstem hemorrhage

127
Q

diffuse axonal injury (DAI)

  • mechanism
  • location
  • ct appearance
  • mri appearance
A
  • accel decel rotation shear injury of axons
  • gray-white junction, corpus callosum, dorsolateral brainstem usually
  • ct is normal or shows diffuse edema
  • mri is more sensitive - multiple poorly defined hyperintense areas in white matter on T2
128
Q

cerebral contusion

  • define
  • location
  • ct appearance
A

hemorrhage from brain impacting skull
frontal or temporal poles usually
heterogenous hyperdense areas in parenchyma on CT

129
Q

how much csf do you make in a day

A

about 400 ml

130
Q

1 common sodium problems post-op (neurosurgery)

A

SIADH - kidneys retain salt (euvolemic or hypervolemic)

cerebral salt wasting - kidneys dump salt (hypovolemic)
-don’t know why, can happen with various brain issues… trauma, stroke, hemorrhage, closed injury…

131
Q 
hydralazine
class
use
mechanism
CI
precaution
A

-vasodilator/antihypertensive
-htn
HFrEF w intolerance to ACEI and ARB eg NYHA class III-IV african-american
-direct vasodilation of arterioles (with little effect on veins)
-Beers potentially inappropriate in 65+ pt w hx of syncope
CAD CI
mitral valve rheumatic heart disease CI
-drug-induced lupus-like syndrome (including glomerulonephritis…)
hypotension
blood dyscrasias
peripheral neuritis

132
Q

pots

define

A

postural tachycardia syndrome
- so tachy with standing… but not always related to autonomic insufficiency like orthostatic hypotension… bp changes can be variable, not always down… various proposed etiologies unclear…

133
Q

test foot for clonus

A

wiggle ankle to loosen then abruptly dorsiflex and hold, better if all leg relaxed so can bend knee into relaxed position too
-normal considered 0-2 beats of clonus, 3 beats or more is hyperreflexic
(neurosurg clinic)

134
Q

chronic steroid toxicity similar to what disease syndrome

A

cushing syndrome

135
Q

major side effects of chronic systemic glucocorticoid therapy

  • derm and soft tissue
  • eye
  • cv
  • gi
  • renal
  • gu
  • bone
  • muscle
  • neuropsych
  • endocrine
  • id
A
  • derm and soft tissue - skin thinning, purpura, cushingoid, alopecia, acne, hirsutism, striae, hypertrichosis
  • eye - posterior subcapsular cataract, inc IOP, exopthalmos
  • cv - arrhythmias w pulse therapy, htn, dyslipidemias, early atherosclerosis
  • gi - gastritis, pud, pancreatitis, steatohepatitis, perf
  • renal - hypokalemia, fluid volume shifts
  • gu - amenorrhea/infertility, intrauterine growth retardation
  • bone - op, avn
  • muscle - myopathy
  • neuropsych - euphoria, dysphoria/depression, insomnia, akathisia, mania, psychosis, pseudotumor cerebri
  • endocrine - dm, hpa insufficiency
  • id - opportunistic infection, inc infections, herpes zoster

(like cushing syndrome)

136
Q

mechanism of adverse effects of chronic systemic steroids

A

those used for chronic disease (prednisone, prednisolone…) don’t have sig mineralcort, androgen, or estrogen activity, so major ae’s from HPA inhibition and iatrogenic cushing syndrome

137
Q

how are steroids antiinflammatory

A
  • inc expression of regulatory and antiinflammatory proteins

- dec expression of proinflammatory proteins

138
Q

cushingoid features

A

body fat redistribution
-truncal obesity, buffalo hump, moon face

weight gain…

Surgery (22 decks)

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