Onset, Regulation And Relative Roles Of The Intrinsic And Extrinsic Coagulation Pathways In Hemostasis And Thrombosis

Question 1

Which pathway is distensible for physiological clot formation?

Answer 1

The intrinsic pathway.

Question 2

Natural mutations in the intrinsic pathway result in a ______ phenotype

Answer 2

Mild

Question 3

What do we expect when one has a mutation in the extrinsic pathway

Answer 3

A major impact on physiological hemostasis

Question 4

Which pathway is dominant in the contex of thrombosis?

Answer 4

The instrinsic pathway

Question 5

What did Thomas Renne study? What did he find?

Answer 5

He studies the effects of every gene in clotting and fibrinolysis in knock out mice and the outcome was that mice with deficiencies in the intrinsic pathway were far more resistant to thrombosis than mice with defects in the extrinsic pathway

Question 6

Where should therapies for thrombosis focus their attention?

Answer 6

On eliminating factor 12, in order to stop the cascade of the intrinsic pathway. This can be done using a specific inhibitor for factor 12