Adult Stem Cells And Stem Cell Niches Flashcards
1
Q
Where are adult stem cells found?
A
In most tissues in the adult organsim, even 'everlasting tissues' Bone marrow Skin GI tract lining Liver Pancreas Adipose tissue Brain heart Skeletal muscle
2
Q
What is a stem cell niche?
A
A discrete anatomical, topographical district of a tissue in which stem cells are found and stemness is maintained
3
Q
What helps stem cells in niches to retain stemness?
A
Close contact with non-stem cell populations
4
Q
What role does the stem cell niche play?
A
It forms a special microenvironment and cells within the niche generate or transmit stimuli that regulate the stem cell self renewal and the generation of progeny cells
5
Q
Do adult stem cells have the same differentiating capacity as ES cells?
A
No, far less.
6
Q
What happens when adult stem cells lose the capacity of self perpetuation?
A
They give rise to cells with restricted developmental potential and are called progenitor cells
