Bizzozzero's Classification Of Tissues

Question 1

Who is G. Bizzozero? When (year) did he perform his most important work

Answer 1

A famous Italian scientist in Biology / Medicine

1884

Question 2

What is Bizozzero’s most famous work?

Answer 2

He utilised Flemming’s technique to visualise chromatin material and improved it - allowing him to observe mitosis in a much more sensitive way.
Bizozzero observed mitosis in different tissues and organs and classed them into 3 major groups

Question 3

Name and describe the 3 categories that Bizozzero classed tissues into based on their regenerative capacities.

Answer 3

• Labile tissues - very high cell turnover and regeneration occurs at all times without the need to be induced
• Stable tissues - very low cell turnover but have the potential to re-enter the cell cyle and divide upon certain stimuli.
• Everlasting tissues - mitosis never occurs, incapable of regeneration

Question 4

Give examples of labile tissues

Answer 4

Intestinal epithelium
Skin epithelium
Surface mucosal epithelia
Spleen 
Bone marrow

Question 5

Give examples of stable tissues

Answer 5

Liver
Kidney
Lung
Bone
Cartilage
Connective Tissue

Question 6

Give examples of everlasting tissues

Answer 6

Nervous tissue
Skeletal muscle
Myocardium

Question 7

Why is observing cell division alone not enough to understand regeneration?

Answer 7

Regeneration requires cell division and MORPHOGENESIS.
The topographial and anatomical relatonships between different cells produce the structure of functional units of that tissue or organ.
Regeneration is therefore equivalent to embryological development

Question 8

Compare regeneration with repair

Answer 8

Regeneration means replacing similar with similar. It implies a full reconstitution of the function.
In Repair, fibroblasts accumulate in the tissue, maintain the matrix and interact with the parenchyma in a functional manner. Dead/damaged cells are replaced with ECM leading to scar formation and fibrosis.