From current understanding of the pathogenesis of atherosclerosis to rational disease control Flashcards
1
Q
Atherosclerosis is an example of which type of inflammation?
A
Sterile inflammation
2
Q
Why have COX inhibitors made no improvements with atherosclerosis
A
They don’t discriminate between sterile and infectious inflammation
3
Q
Selective inhibition of sterile inflammation aims to target…?
A
IL1
4
Q
Why are statins highly effective
A
They decrease LDL levels by 30-40% as they are competitive inhibitors of cholesterol production. Hypercholesterolemia is essential for atherosclerosis hence statins are highly effective
5
Q
Should the repair reaction of the endothelium by smooth muscle cells be a target for therapy?
A
No, since this is simply a defence reaction - aimed at protecting the artery (processes which elicit chronic inflammation should be targeted instead)
