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Medicine > onlinemededanemia > Flashcards

onlinemededanemia Flashcards

1
Q

at what Hgb do you start feeling sxs

A

9

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2
Q

which microcytic anemia has nl Fe, Ferritin, TIBC?

A

thalassemias

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3
Q

sideroblastic anemia iron labs

A

high iron
nl ferritin
nl TIBC

(iron stuck in mitochondria)

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4
Q

etiologies of sideroblastic anemia- reversible vs irreverisble

A

rec: drugs, etoh, lead
irr: B6, MDS

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5
Q

schilling’s test for b12

A

to decipher b12 def etiology

give po b12

if urine pos: B12 nutritional def–>po B12
if urine neg: impaired absorption–>IM b12

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6
Q

treatment for sickle cell

A

hydroxyurea –> inc HgbF

IVF, O2, pain control

exchange transfusion (based on sxs)

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7
Q

treatment for iron overload

A

deferoxamine

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8
Q

drugs that can induce G6PD episode

A

dapsone
bactrim
nitrofurantoin

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9
Q

how to diagnose G6PD disease

A

smear- heinz bodies, bite cells

check G6PD 6-8 weeks after attack

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10
Q

best dx for hereditary spherocytosis

A

osmotic fragility

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11
Q

tx for hereditary spherocytosis

A

splenectomy

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12
Q

autoimmune hemolytic anemia- cold vs warm Ig’s

A

Cold: IgM

Warm: IgG

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13
Q

etiologies and tx of cold hemolytic anemia

A

mycoplasma
mono

tx: avoid the cold

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14
Q

etiologies and tx of warm hemolytic anemia

A

autoimmune, cancer

tx: steroids, rituximab, splenectomy

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15
Q

why PNH is nocturnal?

A

nocturnal –> hypoventilate –> acidosis –> increase MAC –> exacerbate dz

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16
Q

dx of PNH

A

flow cytometry: CD55+

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17
Q

tx PNH

A

supportive

eculizumab

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18
Q

ages of ALL, AML, CML, CLL

A

ALL: 7
AML: 67

CLL: 87
CML: 47

L’s are Xtreme

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19
Q

dx of chronic leukemia vs acute

A

chronic: diff
acute: smear

then both: bm, biopsy

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20
Q

AML dx

A

smear
bx >20% blasts
pos myeloperoxidase

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21
Q

AML tx

A

M3 variant: vit A

otherwise: chemo

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22
Q

ALL dx

A

smears
bm bx >20% blasts
pos CALA and tDt

23
Q

ALL tx

A

chemo

24
Q

which is bcr ablphiladelphia

A

CML

25
Q

tx CML

A

imatinib

26
Q

CLL tx for old asx vs sxs vs young

A

old asx: nothing

old sxs: chemo

young: stem cell transplant

27
Q

which is asx? chronic or acute leukemia?

A

chronic

28
Q

reed sternberg cells for

A

hodgkin’s lymphoma

29
Q

dx for nontender LAD

A

excisional biopsy

30
Q

side effect of cyclophosphamide

A

hemorrhagic cystitis

31
Q

tx for non-hodgkins lymphoma

A

rituximab

32
Q

multiple myeloma sxs pneumonic

A

CRAB

Calcium high
Renal failure
Anemia
Bone pain

33
Q

multiple myeloma dx

A

spep, upep
skeletal survey
bm bx >10% plasma cells

34
Q

multiple myeloma tx

A

> 70 yo: chemo malfagan

<70: stem cell transplant

35
Q

dx and tx of MGUS

A

spep pos, upep neg
skeletal survey neg
bm bx <10% plasma

tx: monitor

36
Q

waldenstrom’s is a high amount of..

A

IgM

37
Q

sxs of waldenstroms

A

hyperviscosity syndrome

constitutional sxs

38
Q

dx waldenstroms

A

spep pos, upep neg
skeletal survey neg
bm bx >10% lymphoma

39
Q

tx waldenstroms

A

rituximab

if hyperviscous –> plasmapheresis

40
Q

sxs of primary (platelet) vs secondary ( PT/PTT) hemostasis

A

1: gingiva, vaginal, petechiae bleeding
2: hemarthrosis, hematoma

41
Q

do NSAIDs and ASA affect platelet count or function?

A

function

42
Q

tx for vWD

A

DDAVP

factor 8 infusions

43
Q

ADAMSTS13 for which dz

A

TTP

44
Q

pathophys for TTP

A

hyaline clot –> shred RBC -> obstruct vessel

45
Q

sxs of TTP

A

FAT RN

Fever
Anemia
Thrombocytopenia
Renal Failure
Neuro sxs
46
Q

Pt/PTT, fibrinogen , d-dimer in TTP

A

all nl

47
Q

TTP tx

A

exchange transfusion

NEVER TRANSFUSE PLATELETS

48
Q

Pt/PTT, fibrinogen , d-dimer in DIC

A

PT/PTT , D-DIMER : up

fibrinogen: down (used up)

49
Q

tx DIC

A

underlying dz

you can transfuse platelets

50
Q

tx of ITP

A

steroids, IVIG
splenectomy
rituximab

51
Q

protein C inhibits factor

A

5

52
Q

factor V leiden path

A

resistance of factor 5 go respond to protein C

53
Q

dx antiphospholipid syn

A

russel viper venom assay

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