onlinemededanemia

Question 1

at what Hgb do you start feeling sxs

Answer 1

9

Question 2

which microcytic anemia has nl Fe, Ferritin, TIBC?

Answer 2

thalassemias

Question 3

sideroblastic anemia iron labs

Answer 3

high iron
nl ferritin
nl TIBC

(iron stuck in mitochondria)

Question 4

etiologies of sideroblastic anemia- reversible vs irreverisble

Answer 4

rec: drugs, etoh, lead
irr: B6, MDS

Question 5

schilling’s test for b12

Answer 5

to decipher b12 def etiology

give po b12

if urine pos: B12 nutritional def–>po B12
if urine neg: impaired absorption–>IM b12

Question 6

treatment for sickle cell

Answer 6

hydroxyurea –> inc HgbF

IVF, O2, pain control

exchange transfusion (based on sxs)

Question 7

treatment for iron overload

Answer 7

deferoxamine

Question 8

drugs that can induce G6PD episode

Answer 8

dapsone
bactrim
nitrofurantoin

Question 9

how to diagnose G6PD disease

Answer 9

smear- heinz bodies, bite cells

check G6PD 6-8 weeks after attack

Question 10

best dx for hereditary spherocytosis

Answer 10

osmotic fragility

Question 11

tx for hereditary spherocytosis

Answer 11

splenectomy

Question 12

autoimmune hemolytic anemia- cold vs warm Ig’s

Answer 12

Cold: IgM

Warm: IgG

Question 13

etiologies and tx of cold hemolytic anemia

Answer 13

mycoplasma
mono

tx: avoid the cold

Question 14

etiologies and tx of warm hemolytic anemia

Answer 14

autoimmune, cancer

tx: steroids, rituximab, splenectomy

Question 15

why PNH is nocturnal?

Answer 15

nocturnal –> hypoventilate –> acidosis –> increase MAC –> exacerbate dz

Question 16

dx of PNH

Answer 16

flow cytometry: CD55+

Question 17

tx PNH

Answer 17

supportive

eculizumab

Question 18

ages of ALL, AML, CML, CLL

Answer 18

ALL: 7
AML: 67

CLL: 87
CML: 47

L’s are Xtreme

Question 19

dx of chronic leukemia vs acute

Answer 19

chronic: diff
acute: smear

then both: bm, biopsy

Question 20

AML dx

Answer 20

smear
bx >20% blasts
pos myeloperoxidase

Question 21

AML tx

Answer 21

M3 variant: vit A

otherwise: chemo

Question 22

ALL dx

Answer 22

smears
bm bx >20% blasts
pos CALA and tDt

Question 23

ALL tx

Answer 23

chemo

Question 24

which is bcr ablphiladelphia

Answer 24

CML

Question 25

tx CML

Answer 25

imatinib

Question 26

CLL tx for old asx vs sxs vs young

Answer 26

old asx: nothing old sxs: chemo young: stem cell transplant

Question 27

which is asx? chronic or acute leukemia?

Answer 27

chronic

Question 28

reed sternberg cells for

Answer 28

hodgkin's lymphoma

Question 29

dx for nontender LAD

Answer 29

excisional biopsy

Question 30

side effect of cyclophosphamide

Answer 30

hemorrhagic cystitis

Question 31

tx for non-hodgkins lymphoma

Answer 31

rituximab

Question 32

multiple myeloma sxs pneumonic

Answer 32

CRAB Calcium high Renal failure Anemia Bone pain

Question 33

multiple myeloma dx

Answer 33

spep, upep skeletal survey bm bx >10% plasma cells

Question 34

multiple myeloma tx

Answer 34

>70 yo: chemo malfagan <70: stem cell transplant

Question 35

dx and tx of MGUS

Answer 35

spep pos, upep neg skeletal survey neg bm bx <10% plasma tx: monitor

Question 36

waldenstrom's is a high amount of..

Answer 36

IgM

Question 37

sxs of waldenstroms

Answer 37

hyperviscosity syndrome constitutional sxs

Question 38

dx waldenstroms

Answer 38

spep pos, upep neg skeletal survey neg bm bx >10% lymphoma

Question 39

tx waldenstroms

Answer 39

rituximab if hyperviscous --> plasmapheresis

Question 40

sxs of primary (platelet) vs secondary ( PT/PTT) hemostasis

Answer 40

1: gingiva, vaginal, petechiae bleeding 2: hemarthrosis, hematoma

Question 41

do NSAIDs and ASA affect platelet count or function?

Answer 41

function

Question 42

tx for vWD

Answer 42

DDAVP | factor 8 infusions

Question 43

ADAMSTS13 for which dz

Answer 43

TTP

Question 44

pathophys for TTP

Answer 44

hyaline clot --> shred RBC -> obstruct vessel

Question 45

sxs of TTP

Answer 45

FAT RN ``` Fever Anemia Thrombocytopenia Renal Failure Neuro sxs ```

Question 46

Pt/PTT, fibrinogen , d-dimer in TTP

Answer 46

all nl

Question 47

TTP tx

Answer 47

exchange transfusion NEVER TRANSFUSE PLATELETS

Question 48

Pt/PTT, fibrinogen , d-dimer in DIC

Answer 48

PT/PTT , D-DIMER : up fibrinogen: down (used up)

Question 49

tx DIC

Answer 49

underlying dz you can transfuse platelets

Question 50

tx of ITP

Answer 50

steroids, IVIG splenectomy rituximab

Question 51

protein C inhibits factor

Answer 51

5

Question 52

factor V leiden path

Answer 52

resistance of factor 5 go respond to protein C

Question 53

dx antiphospholipid syn

Answer 53

russel viper venom assay