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Medicine > immuno tests > Flashcards

immuno tests Flashcards

1
Q

causes of increased ESR

A 
infection
malignancy
inflammatory dz
trauma
ischemia
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2
Q

causes of falsely elevated ESR

A

abnl RBC- PV, spherocytosis, sickle cell

increased WBC

HF

tech errors- clotting oof blood, delay, room temp

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3
Q

CRP characterstics compared to ESR

A

produced by liver

increases and decreases faster than ESR

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4
Q

RA tests and their level of sensitivity/specificty

A

RF - sensitive

CCP/ACPA: specific, bag prognosis

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5
Q

RF positive also for

A

other autoimmune dz

inflamm (hep B, C, TB)

nl in age>60, 5-25%

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6
Q

ANA tested in symptomatic or asx patient?

A

symptomtic

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7
Q

ANA reported how

A

titer

greater the denominator, the stronger the dx

be suspicious with ANA> 1/160

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8
Q

positive ANA if

A

family member with AI disease

female

drugs (hydralazine, monocycline, TNF in)

recent virus

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9
Q

dsDNA

A

lupus

glomerulonephritis

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10
Q

anti-smith

A

specific

lupus

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11
Q

anti-RNP

A

mixed connective tissue disease

lupus

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12
Q

anti-SSA (Ro) and SSB (la)

A

sjogren
lupus
photosensitive
neonatal lupus- heart block

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13
Q

antiphospholipid antibodies types

A

anti- cardiolipin: nonspecific

anti beta GP1: specific

lupus anticoagulant- inc APTT

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14
Q

elevated or decreased C3 causes

A

decreased: used up in active disease or cirrhosis (made in liver)
elevated: infection

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15
Q

scleroderma antibodies

A

anti-centromere- CREST
–> pulm HTN

anti topo I- severe
–> ILD

anti-RNA pol III
–> renal crisis

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16
Q

myositis antibodies

A

HMG coA reducatase

p155/140 - paraneoplastic

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17
Q

anti-tRNA synthetase (anti jo1 ) anitobodies for which dz’s

A

muscle disease

ILD

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18
Q

what % of PMN’s in synovial fluid analysis is indicative of increased risk of septic arthritis?

A

> 75%

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19
Q

rheum joint diseases that can affect 1 joint

A 
trauma
hemarthrosis
spondyloarthropathy
septic arthritis
crystal
20
Q

rheum joint diseases that are oligoarticular

A

spondyloarthropathy
crystal
infection related

21
Q

rheum joint diseases that are polyarticular

A

RLA
SLE
crystal
infectious

22
Q

OA most commonly affects which joints

A 
hands- PIP, DIP
feet- big toe
hips 
AC joint
facet joints of cervical and lumbosacral
23
Q

RA affects which joints

A

wrist, MCP PIP

swan neck, boutonniere

24
Q

RA vs OA which ulnar vs radial deviated

A

RA- ulnar

OA- radial

25
Q

extra- RA manifestation

A

ILD
vaculitis
scleritis
risk of CAD

26
Q

is there kidney involvement in RA?

A

no! think lupus if there is

27
Q

short term vs long term treatment of RA

A

short: prednisone
long: NSAIDS, DMARDs (methotrexate), biologics, hydroxychloroquine

28
Q

treatment for seroneg spondyloarthropathy

A

similar to RA

except no hydroxychloroquine!!

humera good

TNF alpha inhibitors are mainstay

29
Q

short term vs long term treatment for gout

A

short: NSAIDs, colchicine, steroids
long: allopurinol, feboxustat, probenicid

30
Q

pseudogout treatment

A

acute: NSAIDs, colchicine, steroids

long term: methotrexate in refractory cases

31
Q

how should you alter long term allopurinol during gout attack

A

DONT CHANGE DOSE

32
Q

what does malar rash spare

A

nasolabial fold

33
Q

SLE sxs

A

SOAP BRAIN MD

serositis
Oral ulcers
Arthritis
Photosensitive

Blood disorder
Renal disorder
ANA
Immune abnl
Neuro sxs (HA, seizure, MDD, psychosis)

Malar rash
Discoid rash

34
Q

what can improve survival in SLE mild dz?

A

hydroxychloroquine

35
Q

mod-severe dz treatment of SLE

A

azathioprine
mycophenolate mofetil
rituximab
cyclophosphamide

36
Q

short term treatment of SLE

A

prednisone

37
Q

CREST syn

A 
calicnosis
raynauds
Esophageal dysmotility
Scelrodactyly
Telengiecasias
38
Q

raynauds is painful in which phase

A

red

39
Q

lung involvement in scleroderma

A

limited: pulm HTN
diffuse: ILD

40
Q

what to treat scleroderma renal crisis

A

ACEI

NOT PREDNISONE!!

41
Q

how to best treat scleorderma

A

treat each symptom ( eg. CCB for raynauds)

42
Q

is temporal pulse dec or inc in giant cell arteritis

A

decreased

43
Q

treatment for large vessel vasculitis

A

high dose steroids

44
Q

shawl sign, heliotrope rash, mechanic’s hands seen in which disease

A

dermatomyositis

45
Q

diagnosis of myositis

A

biopsy

be suspicious in elevated muscle enzymes and proximal muscle weakness

46
Q

extra-muscle involvement in myositis

A

ILD

malignancy: breast, ovarian, adeno

Medicine (31 decks)

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