oncology passmed questions Flashcards
which cancer is most associated with raised CA 19-9
Pancreatic cancer
which cancer is most associated with CA 125
Ovarian cancer
which cancer is most associated with CA 15-3
breast cancer
CEA is a tumour marker for which cancer
colorectal cancer
__________ is used to suppress nausea and vomiting with intercranial tumours
dexamethasone
what is the nature of inheritance of Gardner’s syndrome
autosomal dominant
what can untreated Gardners syndrome lead to
colorectal cancer
BRCA2 mutation is associated with which cancer in men
Prostate cancer
what is bleomycin used to treat ? what is one of its most adverse side effects ?
metastatic germ cell cancer, squamous cell carcinoma, non Hodgkins lymphoma.
major s/e - lung fibrosis
raised b-HCG with raised alpha fetoprotein is associated with which cancer
Non seminomatous testicular cancer
which condition is superior vena cava associated with
lung cancer
give 5 features of superior vena cava obstruction
dyspnoea
swelling of face, neck and arms
headache
visual disturbances
pulseless jugular venous distension
what is the treatment of choice for SVC obstruction for symptomatic relief
endovascular stenting
what marker is used in PET scan
glucose uptake
what is the earliest and most common symptom of spinal cord compression
Back pain
give 3 other features of spinal cord compression
lower limb weakness
sensory changes
neurological changes
what is the recommended investigation for neoplastic spinal cord compression
whole MRI spine within 24 hours of presentation
what is the management of neoplastic spinal cord compression
high dose oral dexamethasone
urgent oncological assessment for consideration of radiotherapy / surgery
which type of lung cancer has the strongest association with smoking
squamous cell carcinoma
which sub types of HPV are carcinogenic
16, 18 and 33
which condition are HPV 6 and 11 associated with
genital warts
what is a side effect of vincristine
peripheral neuropathy
give 3 adverse effects of cyclophosphamide
haemorrhagic cystitis
myelosuppression
transitional cell carcinoma
which tumours are most likely to cause brain metastases
prostate
breast
lung
give 3 adverse effects of cisplatin
ototoxicity, peripheral neuropathy and hypomagnesaemia
give 3 adverse effects of methotrexate
myelosuppression liver fibrosis and oral mucositis
give an adverse effect of doxorubicin
Paclitaxel
what class of medication is affective at high risk of nausea and vomiting due to chemo
Ondansetron ( 5HT3 receptor antagonists) in conjecture with dexamethasone
what class of medication is affective at low risk of nausea and vomiting due to chemo
metoclopramide
