oncology passmed questions

Question 1

which cancer is most associated with raised CA 19-9

Answer 1

Pancreatic cancer

Question 2

which cancer is most associated with CA 125

Answer 2

Ovarian cancer

Question 3

which cancer is most associated with CA 15-3

Answer 3

breast cancer

Question 4

CEA is a tumour marker for which cancer

Answer 4

colorectal cancer

Question 5

__________ is used to suppress nausea and vomiting with intercranial tumours

Answer 5

dexamethasone

Question 6

what is the nature of inheritance of Gardner’s syndrome

Answer 6

autosomal dominant

Question 7

what can untreated Gardners syndrome lead to

Answer 7

colorectal cancer

Question 8

BRCA2 mutation is associated with which cancer in men

Answer 8

Prostate cancer

Question 9

what is bleomycin used to treat ? what is one of its most adverse side effects ?

Answer 9

metastatic germ cell cancer, squamous cell carcinoma, non Hodgkins lymphoma.

major s/e - lung fibrosis

Question 10

raised b-HCG with raised alpha fetoprotein is associated with which cancer

Answer 10

Non seminomatous testicular cancer

Question 11

which condition is superior vena cava associated with

Answer 11

lung cancer

Question 12

give 5 features of superior vena cava obstruction

Answer 12

dyspnoea
swelling of face, neck and arms
headache
visual disturbances
pulseless jugular venous distension

Question 13

what is the treatment of choice for SVC obstruction for symptomatic relief

Answer 13

endovascular stenting

Question 14

what marker is used in PET scan

Answer 14

glucose uptake

Question 15

what is the earliest and most common symptom of spinal cord compression

Answer 15

Back pain

Question 16

give 3 other features of spinal cord compression

Answer 16

lower limb weakness
sensory changes
neurological changes

Question 17

what is the recommended investigation for neoplastic spinal cord compression

Answer 17

whole MRI spine within 24 hours of presentation

Question 18

what is the management of neoplastic spinal cord compression

Answer 18

high dose oral dexamethasone
urgent oncological assessment for consideration of radiotherapy / surgery

Question 19

which type of lung cancer has the strongest association with smoking

Answer 19

squamous cell carcinoma

Question 20

which sub types of HPV are carcinogenic

Answer 20

16, 18 and 33

Question 21

which condition are HPV 6 and 11 associated with

Answer 21

genital warts

Question 22

what is a side effect of vincristine

Answer 22

peripheral neuropathy

Question 23

give 3 adverse effects of cyclophosphamide

Answer 23

haemorrhagic cystitis
myelosuppression
transitional cell carcinoma

Question 24

which tumours are most likely to cause brain metastases

Answer 24

prostate
breast
lung

Question 25

give 3 adverse effects of cisplatin

Answer 25

ototoxicity, peripheral neuropathy and hypomagnesaemia

Question 26

give 3 adverse effects of methotrexate

Answer 26

myelosuppression liver fibrosis and oral mucositis

Question 27

give an adverse effect of doxorubicin

Answer 27

Paclitaxel

Question 28

what class of medication is affective at high risk of nausea and vomiting due to chemo

Answer 28

Ondansetron ( 5HT3 receptor antagonists) in conjecture with dexamethasone

Question 29

what class of medication is affective at low risk of nausea and vomiting due to chemo

Answer 29

metoclopramide