MSK and rheumatology Flashcards
what is a common laboratory finding in Paget’s disease of the bone
Raised ALP
give 4 features of ankylosing spondylitis on radiograph
Sacroilitis : subchondral erosions , sclerosis
squaring of lumbar vertebrae
bamboo spine
syndesmophytes : ossification of outer fibers of annulus fibrosus
sign of Ankylosing spondylitis on chest xray
Apical fibrosis
what’s the imaging of choice in Osteomyelitis ?
MRI of affected leg and hip
most common cause of septic arthritis in sexually active adults
Neisseria Gonorrhoea
first line investigation for suspected septic arthritis
Synovial fluid sampling
what is an adverse effect of hydrochloroquine
Bulls eye retinopathy - leading to severe and permanent visual loss
most common cause of discitis
Staph. Aureus
how do Gottron’s papules present ? what condition is it present in ?
Roughened red papules over extensor surfaces of fingers. Dermatomyositis
what is the key investigation in patients with suspected septic arthritis
Synovial fluid sampling
what haematological findings are seen in APL
thrombocytopenia
prolonged APTT
which antibody is +ve in APL
Anti cardiolipin antibody
APL syndrome presents with which dermatological finding
Livedo Reticularis
what type of reaction is anaphylaxis
Type 1
how is Reactive arthritis managed ( 1st line and 2nd line)
Analgesia, NSAID’s , intra articular steroids
which inflammatory marker is raised in Polymyalgia rheumatica
ESR
what is the management of Polymyalgia Rheumatica
Prednisolone 15 mg / od
what is the gold standard treatment of SLE
Hydroxychloroquine
which condition is polymyalgia rheumatica associated with ?
Temporal arteritis
what xray feature best supports the diagnosis of polymyalgia rheumatica
Sacro-ilitis on Pelvic xray
what is the first line management of ankylosing spondylitis
exercise regimes and NSAID’s
which antibody is specific and sensitive for Rheumatoid arthritis
Anti cyclic citrullinated peptide
what is the first line management of Raynaud’s
Nifedipine
give 5 early xray findings of RA
Loss of joint space
Juxta-articular osteoporosis
Soft tissue swelling
periarticular erosion
Subluxation
Achilles tendonitis can present with which condition
Ankylosing spondilytis
give 3 xray findings seen in ankylosing spondylitis
Subchondral erosions
sclerosis
squaring of vertebrae
which is the test for SLE with the highest sensitivity
ANA
which are tests for SLE that are highly specific
anti-dsDNA
Anti-smith
why is the use of methotrexate and trimethoprim together contraindicated
it can lead to bone marrow suppression and severe or fatal Ppancytopaenia
what is the management of methotrexate toxicity
folinic acid
what are the instructions for a patient on consuming bisphosphonates
swallow tablets with water while sitting / standing on empty stomach 30 mins before breakfast and stay upright for 30 mins
patients with Sjogren’s syndrome have an increased risk of which malignancy
Lymphoid malignancy
what is the initial management regime for RA
DMARD monotherapy + short course of bridging prednisolone
how do you manage flares of RA
Corticosteroids ( oral /IM)
most common causes of drug induced SLE
procainamide
hydralazine
give 3 less common causes of drug induced SLE
Isoniazid
Minocycline
Phenytoin
which antibodies are positive in APL syndrome
anti-cardiolipin antibodies
T score, what is normal, osteopenia, osteoporosis
> -1 = normal
-1 to -2.5 = Osteopaenia
< - 2.5 = osteoporosis
what is the management when a diagnosis of temporal arteritis is suspected ?
urgent high dose glucocorticoids
what is the most common ocular complication of temporal arteritis
anterior ischaemic optic neuropathy
which tumour presents on radiograph with ‘‘onion skin’’ appearance ?
Ewing’s sarcoma
which is the most common primary malignant bone tumour
Osteosarcoma
ewing’s sarcoma most commonly affects which bones
pelvis + long bones
give 2 features seen on xray in Osteosarcoma
Codman triangle
sunburst pattern
how does giant cell tumour present on xray
double bubble / soap bubble
what is the most common benign bone tumour
Osteochondroma
which scoring system is used as a disease measure of RA
DAS28
'’plantar spur’’ and ‘‘pencil in cup’’ deformity are typical xray features seen in __________.
Psoriatic arthritis
is psoriatic arthritis symmetrical or asymmetrical ?
Asymmetrical
give 3 expected findings on examination of chest and spine in ankylosing spondylitis
reduced chest expansion
reduced lateral flexion
reduced forward flexion
is azathioprine safe to use in pregnancy
yes
which xray finding can be used to distinguish gout from pseudogout ?
pseudogout : chondrocalcinosis
gout : no chondrocalcinosis
how long do symptoms need to be present for a diagnosis of chronic fatigue syndrome to be made ?
3 months
give 3 features of inflammatory arthritis
pain in the morning
systemic features
raised inflammatory markers
_______ presents with pain and tenderness over the lateral side of the thigh
trochanteric bursitis
how does meralgia paraesthetica present
compression of lateral cutaneous nerve of thigh with a burning sensation of antero-lateral aspect of thigh
give 5 side effects of methotrexate
mucositis
myelosuppression
pneumonitis
pulmonary fibrosis
liver fibrosis
what is the drug given to manage methotrexate toxicity
Folinic acid
blue sclera is associated with _______
osteogenesis imperfecta
how does pseudogout present under the microscope ?
weakly +ve bi-fringent rhomboid shaped crystals
what is the imaging of choice for achilles tendon rupture
ultrasound
what are the red flag features of suggesting an alternative diagnosis to osteoarthritis
rest pain
night pain
morning stiffness >2 hours
which finger joints are more commonly affected in osteoarthritis
PIP
DIPJ
patients with ________ often get relief from shaking their hands
Carpal tunnel syndrome
what are the red flags for lower back pain
age < 20, >50
history of previous malignancy
night pain
history of trauma
systemically unwell ( weight loss and fever)
what is the most appropriate investigation to confirm the diagnosis of ACL injury
MRI
what is the most common PCL injury
Dashboard injury , occurs when knee is flexed
ACL injury caused by hyperextension / flexion ?
Hyperextension
what test can be performed to test for PCL damage
Posterior draw test
which structure is divided in surgical management of carpal tunnel syndrome
flexor retinaculum
prescribing folate with methotrexate reduces the risk of _________
Myelosuppression
what is the most common form of hip dislocation
Posterior dislocation
how does posterior dislocation of the hip present
affected leg is shortened, adducted and internally rotated
how does anterior dislocation of the hip present
affected leg is abducted and externally rotated ; no leg shortening
which type of back pain is a red flag symptom
thoracic back pain
what is the investigation of choice for Cauda Equina syndrome ?
MRI Spine
what is a late sign of cauda equina syndrome
Urinary incontinence
in how many hours should a patient with suspected cauda equina receive an MRI
6 hours
What type of injuries lead to meniscal tears?
Twisting injuries
what test can be used to check for a meniscal tear
Thessaly’s test
which 2 arteries mainly supply the hip joint ?
medial and lateral circumflex femoral arteries
damage to the medial circumflex femoral artery can lead to __________
Avascular necrosis of the femoral head
which 3 nerves supply the hip joint
sciatic femoral and obturator nerves
what is the classical sign of a hip fracture
shortened and externally rotated leg
what is a key sign on x-ray of NOF Fracture
Shenton’s line
Biceps rupture may lead to a ———– deformity in the middle of the upper arm
Popeye
how are simple rib fractures managed ?
Conservative management with analgesia
what is a serious complication of rib fracture
Pneumothorax
what is the management of lumbar canal stenosis ?
Laminectomy
what is the management of a displaced intracapsular fracture ?
Hemiarthroplasty
cubital tunnel syndrome occurs due to the compression of which nerve ?
ulnar nerve
what is the key feature of cubital tunnel syndrome?
Tingling and numbness of 4th and 5th finger, starting off as intermittent and then becoming constant.
how does L5 disc prolapse present
loss of foot dorsiflexion and sensory loss on the dorsum of the foot
how does S1 nerve root compression present ?
sensory loss posterolateral aspect of leg and lateral aspect of foot
weakness in plantar flexion
reduced ankle reflex
What is the most common location for Ganglion ?
how does it present ?
Dorsal aspect of the wrist. Presents as a firm and well circumbscribed mass that trans-illuminates
how does a ganglion present
firm and well circumscribed mass that trans-illuminates
In a child with an asymptomatic, fluctuant swelling behind the knee the most likely diagnosis
Baker’s cyst
which nerve is most likely to be injured during knee arthroplasty
common peroneal nerve
what is raloxifene used for ? what is its mechanism ?
selective oestrogen receptor modulator and mimics the effect of oestrogen on bone - used for management of post menopausal osteoporosis
inhibition of osteoclast activity
what are the symptoms seen in in Behcet’s syndrome?
oral ulcers
genital ulcers
anterior uveitis
thrombophlebitis and DVT
erythema nodosum