dermatology Flashcards
what is a Pyogenic Granuloma? how does it present?
What are the triggers for it ?
where does it mainly occur?
what important differential needs to be excluded ?
It is a benign rapidly growing tumour of capillaries that presents as a discrete lump with a red or dark appearance that grows rapidly upto 1-2 cm in size.
Triggers:
Follows trauma
pregnancy
hormonal contraception
infection
occurs on fingers/ upper chest/ back / neck/ head
Nodular melanoma needs to be excluded
what are the areas commonly affected by acne rosacea ? how does it present
typically affects nose, cheeks and forehead
first symptom : flushing
telangiectasia : common
develops into erythema with papules and pustules
how would you manage acne Vulgaris that has not responded to topical and oral therapies
refer to dermatology for prescription of Isotretinoin
what is an alternative to tetracyclines that can be used in pregnant women for the management of acne vulgaris
erythromycin
how does idiopathic livedo reticularis present
purple, lace patterned discolouration of the skin and worsening of the symptoms in the cold.
how does miliaria present
rash characterised by small, raised spots that are often red on white skin and colourless on brown and black skin
what is the first line management of scalp psoriasis
topical corticosteroid
what is the Koebner phenomenon ? What conditions does it appear in?
skin lesions that appear at the site of injury
psoriasis, vitiligo, warts, lichen planus, lichen sclerosus, molluscum contagiosum
what is guttate psoriasis
psoriatic condition clasically occuring after infections such as strep throat
how soon after an strep infection does guttate psoriasis present
2-4 weeks after infection
how does a venous ulcer present ?
aching lower limb
ulceration in the ‘‘gaiter region’’
night cramps or cramps that occur after sitting or active standing
symptom relief from leg elevation
skin discolouration
how do you investigate a venous ulcer ?what value indicates arterial disease ?
ABPI ( Value < 0.9 indicates arterial disease)
what is the management of venous ulcer
compression bandage
what is the difference between bullous pemphigoid and pemphigus
Both are auto-immune blistering disorders affecting the elderly.
a Pemphigus presents with blisters and erosions involving the mucous membranes whereas a pemphigoid does not involve the mucosa
which parts does rosacea affect
nose cheeks and forehead
give 3 features of rosacea
flushing, Erythema, telangiectasia
how is pityriasis versicolor managed
Ketoconazole shampoo
give 4 features of pityriasis versicolor
affects trunk
hypo-pigmented, pink or brown patches
more prominent after a suntan
scale
pruritis
first line management of scabies
Permethin
what is Nikolsky sign ? In which condition is it present ?
Blisters and Erosions that appear when the skin is rubbed gently . Seen in Stevens Johnson syndrome, toxic epidermal necrolysis
what is the classical sign seen in Erythema multiforme
Target sign
what is Erythema Multiforme triggered by
Infection
What is Actinic Keratosis
It is a common Pre-malignant condition that develops as a consequence of chronic sun exposure.
where does actinic keratosis commonly occur and how does it present ?
Small crusty or scaly lesions on sun exposed areas like the temple of head
what are the management options for actinic keratosis
prevention : Sun cream
Florouracil : 2-3 week course
topical diclofenac / topical imiquimod
whats a condition that features hair loss after pregnancy
Alopecia areata
give 3 features of pyoderma gangrenosum
Initially a small red papule
followed by deep, red, necrotic ulcer with a violaceous border
idiopathic in 50% of cases and can be seen in IBD, Connective tissue disorders and Myeloproliferative disorders
A man presents with a growing round raised flesh colored lesion with central depression and Telangiectasia . What is the diagnosis ?
BCC
which condition presents with the formation of corkscrew shaped collateral vessels distally- What is the strongest association for this condition
Buerger’s disease
smoking
what is the treatment of -
mild/moderate acne Rosacea
severe/ resistance Rosacea
mild : Topical Ivermectin
Severe/ resistant : combination of topical Ivermectin and oral doxycycline
which is the single most important prognostic factor in malignant melanoma ?
Invasion of the tumour
2 key features of Toxic epidermal necrolysis
systemically unwell ( pyrexia, tachycardia)
Positive Nikolsky’s sign : epidermis separates with mild lateral pressure
name 2 complications of toxic epidermal necrolysis
Volume loss
Electrolyte derangement
name 6medication triggers of TEN
PSA PCN
Phenytoin
Sulphonamides
Allopurinol
Penicillins
Carbamazepine
NSAIDs
Under what circumstances would you refer a patient with molluscum contagiosum
HIV +ve with extensive lesions
what is the name of the rash caused by TB
Erythema nodosum
which malignancy is most commonly associated with acanthosis nigricans
Gastrointestinal adenocarcinoma
first line treatment for non bullous impetigo
Hydrogen peroxide 1% cream
do you need a break when prescribing topical steroids in patients with psoriasis ?
yes, 4 week break in between courses
what is the antibiotic of choice for acne in pregnancy? Can it be used alone
Oral erythromycin, to be used with Benzoyl peroxide. do not use Abx alone as it can lead to antibiotic resistance.
which medications should not be used in combination in the management of acne vulgaris
Topical and oral antibiotics
what is an alternative to oral antibiotics in the management of acne in women
COCP
_____________ is a contraindication to topical and oral retinoid treatment
pregnancy
what is the first line management of mild-moderate acne
12 week course of topical combination therapy such as :
- topical adapalene with topical benzoyl peroxide
- Topical tretinoin with topical clindamycin
- topical benzoyl peroxide with topical clindamycin
which malignancy are patients who have undergone renal transplant most at risk of developing
skin cancer ( Squamous cell carcinoma)
What is the first line medical manegement of actinic keratosis
Florouracil cream ( 2-3 week course)
what are Curling’s ulcers ? How do they present ?
Gastric ulcers that develop in response to severe physiological stress such as burns. presents as haematemesis
give 3 characteristic features of acne vulgaris
Open and closed comedones
Pustules
Nodules
Name 5 nail changes that may be present in psoriasis
Pitting
Onycholysis
Subungal Hyperkeratosis
loss of the nail
dactylitis and enthesitis
name 5 nail changes that maybe seen in psoriasis
Pitting
Onycholysis ( seperation of nail from nail bed)
subungual hyperkeratosis
loss of the nail
dactylitis and enthesitis
what is the first line management of Bowens disease
5- Fluorouracil
where is venous ulceration most commonly seen
above the medial malleolus
what medications exacerbate psoriasis
MALIN B
( anti) Malarials
ACEi
Lithium
Infliximab
NSAID’s
Beta blockers
what is the nature of inheritance of hereditary haemorrhagic telangiectasia ? describe it.
autosomal dominant. Characterised by telangiectasia over the skin and mucous membranes as well as features like epistaxis, visceral lesions and a family history
what are the 4 diagnostic criteria used to diagnose HHT
- Epistaxis : Spontaneous, recurrent nosebleeds
Telangiectasias : multiple at different sites ( Lips, oral cavity, fingers, nose)
visceral lesions ( AVM’s)
Fhx : 1st degree relative
how would you differentiate pyogenic granuloma from amelanotic melanoma
pyogenic granuloma has a history of trauma
how do you investigate contact dermatitis
Patch testing
how long does it take for the pityriasis rosea rash to resolve
6-12 weeks
classical sign of pityriasis rosea
herald sign
Wikham striae are present in which condition
lichen planus
which gi condition is pyoderma gangrenosum associated with
IBD
which condition is high voltage burns associated with ?
Rhabdomyolysis
what are the 2 types of Comedones
top closed–> whitehead
top open –> blackhead
when follicles burst releasing irritants, the following types of inflammatory lesions are formed
nodules and cyst
what are the 2 types of scars that can be formed due to excessive inflammatory response in acne vulgaris
ice pick scars
hypertrophic scars
what is acne fulminans
severe acne associated with systemic upset ( fever)
what is a consequence of long term antibiotic use in acne. how do you treat this
gram negative folliculitis. treat with high dose oral trimethoprim
________ is a contraindication to topical and oral retinoid treatment
Pregnancy
To reduce the risk of antibiotic resistance developing the following should not be used to treat acne:
-monotherapy with a topical antibiotic
-monotherapy with an oral antibiotic
-a combination of a topical antibiotic and an oral antibiotic
what is the management of mild to moderate acne that has not responded to 2 completed courses of treatment
consider referral
what is the first line management of plaque psoriasis ?
potent corticosteroid such as betamethasone applied once daily plus vitamin D analogue applied OD
what are dermoid cysts and what can they be lined by
embryological remnants and may be lined by hair and squamous epithelium
what are the 4 p’s of lichen planus
purple
pruritic
papular
polygonal
how do you manage dermatophyte nail infections
oral terbinafine
which medications can cause depigmentation in patients with darker skin
topical corticosteroids such as clobetasone
what is the management of mild to moderate acne rosacea with pustules and papules ?
Topical ivermectin
what is the management of moderate to severe papules and pustules
combination of topical ivermectin and oral Doxycycine
how is erythema and flushing managed in acne rosacea ?
Topical brimonidine gel
which condition presents with orange peel shins
graves disease
How many weeks should be given between courses of topical corticosteroids
4 week break
what is the first line management of chronic plaque psoriasis ? How long is the treatment continued ?
potent corticosteroid applied once daily plus vitamin D Analogue applied once daily - for up to 4 weeks
what is the first line management of urticaria
non sedating anti histamines such as certizine
what is used for severe / resistant cases of urticaria
Prednisolone
what is used in the long term management of chronic plaque psoriasis
vitamin D Analogues such as calcipotriol, calcitriol
which medications exacerbate psoriasis
beta blocker
lithium
anti malarial
NSAIDs
ACEi
Infliximab
which malignancy are patients who undergo renal transplant at risk of
squamous cell carcinoma of the skin
what test is most appropriate for diagnosing contact dermatititis ?
Skin patch testing
what type of hypersensitivity reaction is allergic contact dermatitis?
Type 4