Oncology Flashcards
When increasing dose of opiates how much do you increase by?
30-50%
What can be used for bone met pain in palliative care?
Strong opioids
Bisphosphonates
Radiotherapy.
Ca 15-3
Breast ca
Ca 125
Ovarian
When can AFP be raised
Liver ca
Teratomas
What tumour markers may be elevated in testicular ca in what situations
Seminomas: hCG may be elevated in around 20%
Non-seminomas: AFP and/or beta-hCG are elevated in 80-85%
LDH is elevated in around 40% of germ cell tumours
What are the types of testicualr ca?
Germ cell = most common (95%)
These can be further split into:
Seminoma
Non-seminoma - embryonal, yolk sac, teratoma and choriocarcinoma
Non-germ cell tumours include Leydig cell tumours and sarcomas.
CEA
colorectal ca
s-100
melanoma/schwannoma
Bombesin
Small cell lung carcinoma, gastric cancer, neuroblastoma
Cyclophosphamide SEs
Haemorrhagic cystitis, TCC
Bleomycin SE’s
Pulmonary fibrosis
Anthracyclines example and SE
Doxorubicin
Cardiotoxicity
Cisplatin SE’s
Ototoxicity, nephrotoxicity, peripheral neuropathy, low mg
Vincristine SE’s
Peripheral neuropathy
Asparagine SEs
Neurotoxicity
Codeine to morphine conversion
divide by 10
How to get from
1) Oral morph to s/c morph
2) Oral morph to s/c diamorph
1) divide by 2
2) divide by 3
First line drug for confusion in palliative care
Haloperidol
What antiemetic for chemical stuff e.g. chemo/opiates
Ondansetron/haloperidol/levo
what antiemetic for mechanical obstruction
Metoclopromide
What antiemetic for raised ICP
Cyclizine
Which 2 main chemo agents cause peripheral neuropathy and when would each be used?
Vincristine - Lymphoma
Cisplatin
Methotrexate SEs
Myelosuppression, liver fibrosis and oral mucositis
