MSK Flashcards

1
Q

Which nerve is affected in carpal tunnel?

Which fingers do you get symptoms

A

Median

Thumb, index and middle

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2
Q

Polymyalgia rheumatic key features

Key Ix

Management?

A
  • Usually pts > 60
  • Usually rapid onset (e.g. < 1 month)
    aching, morning stiffness in proximal limb muscles

also mild polyarthralgia, lethargy, depression, low-grade fever, anorexia, night sweats

ESR (inflam markers will be up)

Steroids

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3
Q

How to manage Carpal tunnel

A

Mild-moderate:
6 week trial of conservative treatments e.g.
corticosteroid injection, wrist splints at night.

If severe/conservative measures don’t help:
surgical decompression (flexor retinaculum division)

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4
Q

FRAX used risk factors for osteoporosis

A

Bones SPARC

BMI (low)
Smoking
Parental hip fracture
Alcohol XS
Rheumatoid arthritis
Corticosteroid use (more than 3 months at a dose of prednisolone 10mg daily)

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5
Q

What do DXA results mean?

A

> -1 = normal
-1-> -2.5 osteopoenia
< - 2.5 osteoporosis.

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6
Q

Osteoporosis management - lifestyle

A

Falls risk assessment, weight bearing and muscle strengthening exercises, adcal, calculate FRAX

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6
Q

When would you use bisphosphonates in osteoporosis

A

if 10y risk of fracture >1%
OR
hip or vertebral fracture
OR
T score <-2.5 or less at femoral neck
OR
T-score between -1 and -2.5 (osteopoenic) AND 10y probability of a hip fracture >3%

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7
Q

What can be used for osteoporosis above bisphosphonates if indicated

A

Denosumab

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8
Q

What is Tennis elbow?
How do you test for it?

A

lateral epicondylitis

Get pt to hold arm at 90 degrees whilst supinated then push wrist down into your hand (extend wrist) - will reproduce pain.

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9
Q

What is golfers elbow?
How do you test for this?

A

medial epicondylitis

Get pt to hold arm at 90 degrees whilst supinated then flex wrist (I’m pointing to ME)

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10
Q

What condition is anti phospholipid syndrome most commonly associated with

A

lupus

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11
Q

What happens to coag in anti phospholipid syndrome

A

Prolonged APTT

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12
Q

Features of anti-phospholipid syndrome?

A

Clots, recurrent miscarriages, low platelets

livedo reticularis

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13
Q

How to investigate anti phospholipid syndrome

A

Antibodies:
- Anticardiolipin antibodies
- Anti-beta2 glycoprotein I (anti-beta2GPI)

Lupus anticoagulant
FBC (thrombocytopenia)
Coag (prolonged APTT_

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14
Q

Anti phospholipid syndrome management

A

Aspirin

If pt develops a clot then warfarin

If they get another clot whilst on this increase target INR to 3-4 and consider adding aspirin

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15
Q

Other ank spond Features

A

Apical fibrosis
Anterior uveitis
Aortic regurgitation
Achilles tendonitis
AV node block
Amyloidosis

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16
Q

What is cubital tunnel

When can symptoms be worse?

A

Little and ring finger affected
Ulnar nerve

Can be worse when leaning on the affected elbow. Often assoc w. trauma/ OA to the area

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17
Q

First line bisphosphonate for osteoporosis

A

Aledronate

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18
Q

When are bisphosphonates C/I?

A

eGFR less than 35

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19
Q

X ray changes in OA?

A

LOSS

Loss of joint space
Osteophytes forming at joint margins
Subchondral sclerosis
Subchondral cysts

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20
Q

Which autoantibody has the highest specificity for RA?

A

Anti CCP

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21
Q

In what other conditions might RF be positive

A

Felty’s syndrome (around 100%)

Sjogren’s syndrome (around 50%)

Infective endocarditis (around 50%)

SLE (= 20-30%)

systemic sclerosis (= 30%)

general population (= 5%)
rarely: TB, HBV, EBV, leprosy

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22
Q

Classic radiograph features of osteosarcoma

A

Radiographs classically show Codman triangle (a triangular area of new subperiosteal bone) with an associated sunburst appearance.

23
Q

Classic radiograph features of Ewing’s sarcoma

A

Onion skin

24
What condition is osteosarcoma associated with
Retinoblastoma
25
What is a fragility fracture
Fall from standing height or less
26
If pt over 75 falls and get a fragility fracture what do you do
Start bisphosphonates
27
When would you start bisphoshonates in women without screening
If over 50 and had a fragility fracture
28
meralgia paraesthetica - which nerve is affected?
Lateral cutaneous nerve of the thigh
29
Pseudogout microscopy
Positively bifringent crystals.
30
Gout timeline
Reaches maximum intensity within 24 hours, and resolves within 5-15 days.
31
What do gout crystals look like? What do pseudo gout crystals look like? What are the made of?
Gout: Negatively bifringent Needle shaped Monosodium urate Pseudogout: Positively bifringent Rhomboidal Calcium pyrophosphate
32
Chronic Gout x ray appearances
Joint effusion is usually the earliest sign. Later, x-rays show punched out lytic lesions, sclerotic margins and outlines of tophi. Top are caused by MSU Crystal deposition
33
What is pseudo gout also called?
Calcium Pyrophosphate Deposition Disease
34
Main differences in management gout/pseudogout
Pseudogout - rate lowering therapies won't work
35
Osteomalacia sx
-Bone pain -Bone/muscle tenderness -Fractures: especially femoral neck -Proximal myopathy: may lead to a waddling gait
36
What blood results would you expect in osteomalacia? What would XR look like?
Bloods: - low vitamin D - low calcium, phosphate (in around 30%) - Raised alkaline phosphatase (in 95-100% of patients) x-ray translucent bands (Looser's zones or pseudofractures)
37
How to treat osteomalacia?
Vit D supplement
38
What is Finkelstein's test and what does it indicate?
Pulls the thumb of the patient in ulnar deviation and longitudinal traction. Indicates De Quervain's tenosynovitis. This is where the sheath containing the extensor pollicis brevis and abductor pollicis longus tendons is inflamed.
39
How to start allopurinol for gout?
Initial dose of 100 mg od. Titrate every few weeks to aim for a serum uric acid of < 360 µmol/ Colchicine cover (NSAIDS if can't tolerate)
40
When should bisphosphonates be taken?
At least 30 mins before breakfast with lots of water, sit upright for 30 mins after
41
Knee pain and a history of lots of kneeling?
Infrapatellar bursitis
42
when would you start bisphosphonates without investigating?
If over 75 and sustained a fragility fracture
43
Reactive arthritis classic features and other name
Reiters syndrome. Joint pain, conjunctivitis, urethritis can't see, pee or climb a tree
44
Which antibodies most common in Sjogrens
Anti-Ro rheumatoid factor (RF) positive in nearly 50% of patients ANA positive in 70% anti-Ro (SSA) antibodies in 70% of patients with PSS anti-La (SSB) antibodies in 30% of patients with PSS
45
Common cause of lateral knee pain in runners?
Iliotibial band syndrome
46
Subacromial impingement examination signs
painful arc of abduction. With subacromial impingement, this is typically between 60 and 120 degrees.
47
What does CREST syndrome indicate and what does it stand for
Limited systemic sclerosis Calcinosis Raynaud's phenomenon oEsophageal dysmotility Sclerodactyly Telangiectasia
48
3 subtypes of systemic sclerosis
Limited systemic sclerosis (CREST) Diffuse cutaneous systemic sclerosis Scleroderma
49
Which antibodies are associated with systemic sclerosis and which subtypes
Antibodies ANA positive in 90% RF positive in 30% anti-scl-70 antibodies associated with diffuse cutaneous systemic sclerosis associated with a higher risk of severe interstitial lung disease anti-centromere antibodies associated with limited cutaneous systemic sclerosis
50
Diffuse cutaneous systemic sclerosis features
- Trunk and proximal limbs mainly affected - anti scl-70 antibodies the most common cause of death is now respiratory involvement, which is seen in around 80%: interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) other complications include renal disease and hypertension poor prognosis
51
Which DMARD can cause oligospermia
Sulfasalzine Also ILD and Heinz body anaemia
52
How to manage acute flare of RA
IM Methylpred
53
When would you give a TNF inhibitor in RA
If inadequate response to 2 DMARDs
54