Oncogenes assoc. w/ disease

Question 1

ABL

Answer 1

Proto-oncogene/tumor promoter

CML, ALL

Question 2

APC/beta-catenin

Answer 2

Tumor supressor

Stomach cancer, Colon cancer, Pancreatic cancer, familial adenomatous polyposis (FAP)

Question 3

BRAF

Answer 3

Proto-oncogene/tumor promoter

Melanoma

Question 4

HER1

Answer 4

Proto-oncogenes/tumor promoters

Squamous cell lung cancer

Question 5

BRCA1/BRCA2

Answer 5

Tumor suppressor

Breast cancer, ovarian cancer

Question 6

DCC

Answer 6

Tumor suppressor

Colon cancer

Question 7

ERBB2/HER2

Answer 7

Tumor promoter

Breast cancer, ovarian cancer

Question 8

MYC

Answer 8

Tumor promoter

• Neuroblastoma (NMYC);
• Small cell lung cancer (LMYC);
• Burkitt lymphoma (c-MYC)

Question 9

NF1

Answer 9

Tumor supressor

Neuroblastoma neurofibromatosis type1, sarcoma

Question 10

RAS

Answer 10

Proto-oncogenes/tumor promoters

Lung cancer, colon cancer, pancreatic cancer (KRAS);
Renal cell cancer, bladder cancer (HRAS)

Question 11

SIS

Answer 11

Proto-oncogenes/tumor promoters

Astrocytoma, osteosarcoma

Question 12

TFGA

Answer 12

Proto-oncogenes/tumor promoters

Astrocytoma, hepatocellular carcinoma

Question 13

RB

Answer 13

Tumor suppressor

• Retinoblastoma
• Osteosarcoma (familial form)
• many other cancers

Question 14

TP53

Answer 14

Tumor suppressor

Most cancers, Li-Fraumeni syndrome

Question 15

VHL

Answer 15

Tumor suppressor

Von Hippel-Lindau syndrome, renal cell cancer

Question 16

WT1

Answer 16

Tumor suppressor

Wilms tumor

Question 17

MSH2/MLH1

Answer 17

DNA mismatch repair

- Lynch syndrome (HNPCC)

Question 18

PDGFB

Answer 18

Tumor promoter

- Astrocytomas

Question 19

RET

Answer 19

Tumor promoter

• MEN2A/B
• Thyroid medullary carcinoma

Question 20

KIT

Answer 20

Tumor promoter

- GI stromal tumor

Question 21

CCND1/cyclin D1

Answer 21

Tumor promoter

- Mantle cell lymphoma

Question 22

CDK4

Answer 22

Tumor promoter

- Melanoma