Oncogenes and TSGs

Question 1

BCR-ABL

Answer 1

Oncogene; assoc. w/ CML, ALL; t(9;22)

Question 2

bcl-2

Answer 2

Oncogene; assoc. w/ follicular & undifferentiated lymphomas; t(14;18)

Question 3

BRAF

Answer 3

Oncogene; assoc. w/ melanoma

Question 4

c-kit

Answer 4

Oncogene; assoc. w/ gastrointestinal stromal tumor (GIST)

Question 5

c-myc

Answer 5

Oncogene; assoc. w/ Burkitt lymphoma; t(8;14)

Question 6

HER2/neu (c-erbBw)

Answer 6

Oncogene; assoc. w/ breast, ovarian, & gastric carcinomas

Question 7

L-myc

Answer 7

Oncogene; assoc. w/ lung cancer

Question 8

N-myc

Answer 8

Oncogene; assoc. w/ neuroblastoma

Question 9

ras

Answer 9

Oncogene; assoc. w/ colon cancer, lung cancer, pancreatic cancer

Question 10

ret

Answer 10

Oncogene; assoc. w/ MEN 2A & 2B, sporadic medullary carcinoma of the thyroid

Question 11

APC

Answer 11

TSG; assoc. w/ colorectal cancer (FAP-related)

Question 12

BRCA1/2

Answer 12

TSG; assoc. w/ breast and ovarian cancer

Question 13

CPD4/SMAD4

Answer 13

TSG; assoc. w/ pancreatic cancer

Question 14

DCC

Answer 14

TSG; assoc. w/ colon cancer

Question 15

MEN1

Answer 15

TSG; assoc. w/ MEN type 1

Question 16

NF1

Answer 16

TSG; assoc. w/ neurofibromatosis type 1

Question 17

NF2

Answer 17

TSG; assoc. w/ neurofibromatosis type 2

Question 18

p16

Answer 18

TSG; assoc. w/ melanoma

Question 19

p53

Answer 19

TSG; assoc. w/ most human cancers, Li-Fraumeni syndrome

Question 20

PTEN

Answer 20

TSG; assoc. w/ breast cancer, prostate cancer, endometrial cancer

Question 21

Rb

Answer 21

TSG; assoc. w/ retinoblastoma, osteosarcoma (inhibits E2F)

Question 22

TSC1/2

Answer 22

TSG; assoc. w/ tuberous sclerosis

Question 23

VHL

Answer 23

TSG; assoc. w/ von Hippel-Lindau disease (inhibits HIF1a)

Question 24

WT1/2

Answer 24

TSG; assoc. w/ Wilms Tumor (nephroblastoma