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First Aid > First Aid - Pathology - Tumor Associations > Flashcards

First Aid - Pathology - Tumor Associations Flashcards

1
Q

acanthosis nigricans

A

visceral malignancy

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2
Q

actinic keratosis

A

SCC of skin

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3
Q

AIDS

A

aggressive malignant lymphomas (non-Hodgkin) and Kaposi sarcoma

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4
Q

AI diseases (Hashimoto’s, SLE)

A

Lymphoma

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5
Q

Barrett’s

A

esophageal adenocarcinoma

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6
Q

chronic atrophic gastritis, pernicious anemia, postsurgical gastric remnants

A

gastric adenocarcinoma

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7
Q

cirrhosis

A

HCC

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8
Q

Cushing syndrome

A

small cell lung cancer

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9
Q

Dermatomyositis

A

lung cancer

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10
Q

down syndrome

A

ALL AML

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11
Q

dysplastic nevus

A

malignant melanoma

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12
Q

hypercalcemia

A

squamous cell lung cancer

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13
Q

immunodeficiency states

A

malignant lymphomas

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14
Q

Lambert-Eaton myasthenic syndrome

A

small cell lung cancer

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15
Q

myasthenia gravis, pure RBC aplasia

A

thymoma

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16
Q

paget’s disease of bone

A

secondary osteosarcoma and fibrosarcoma

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17
Q

plummer-vinson syndrome (dec. iron)

A

squamous cell carcinoma of esophagus

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18
Q

polycythemia

A

renal cell carcinoma, HCC

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19
Q

radiation exposure

A

leukemia, sarcoma, papillary thyroid cancer and breast cancer

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20
Q

SIADH

A

small cell lung cancer

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21
Q

Tuberous sclerosis (facial angiofibroma, seizures, intellectual disability)

A

giant cell astrocytoma, renal angiomyolipoma, and cardiac rhabdomyoma

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22
Q

ulcerative colitis

A

colonic adenocarcinoma

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23
Q

xeroderma pigmentosa, albinism

A

melanoma, basal cell carcinoma, SCC of skin

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24
Q

oncogenes

A

BCR-ABL, bcl2, BRAF, c-kit, c-myc, HER2/neu, L-myc, N-myc, ras, ret

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25
Q

BCR-ABL

A

CML, ALL

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26
Q

bcl2

A

follicular and undifferentiated lymphomas

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27
Q

BRAF

A

melanoma

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28
Q

c-kit

A

GI stromal tumor

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29
Q

c-myc

A

Burkitt lymphoma

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30
Q

HER2/neu

A

breast, ovarian and gastric carcinoma

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31
Q

L-myc

A

lung tumor

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32
Q

N-myc

A

neuroblastoma

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33
Q

ras

A

colon cancer, lung cancer and pancreatic cancer

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34
Q

ret

A

MEN2A and 2B

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35
Q

tumor suppressor genes

A

APC, BRCA1, BRCA2, CPD4/SMAD4, DCC, MEN1, NF1, NF2, p16, p53, PTEN, Rb, TSC1, TSC2, VHL, WT1, WT2

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36
Q

APC

A

colorectal cancer (FAP)

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37
Q

BRCA1

A

breast and ovarian cancer in women

38
Q

BRCA2

A

breast in men

39
Q

CPD4/SMAD4

A

pancreatic cancer

40
Q

DCC

A

colon cancer

41
Q

MEN1

A

MEN type 1

42
Q

NF1/NF2

A

neurofibromatosis 1/2

43
Q

p16

44
Q

p53

A

most cancers, li-fraumani syndrome

45
Q

PTEN

A

breast cancer, prostate cancer, endometrial cancer

46
Q

Rb

A

retinoblastoma, sarcoma

47
Q

TSC1/2

A

tuberous sclerosis

48
Q

VHL

A

von-hippel lindau disease

49
Q

WT1/2

A

Wilm’s tumor

50
Q

tumor markers

A

ALP, aFP, b-hCG, CA15-3, CA27-29, CA19-9, CA125, calcitonin, CEA, PSA, S100, TRAP

51
Q

ALP

A

metastases to bone, liber, paget’s disease of bone, seminoma (placental ALP)

52
Q

aFP

A

HCC, hepatoblastoma, yolk sac tumor, testicular cancer, mixed germ cell tumor

53
Q

b-hCG

A

hydatidiform moles and choriocarcinomas, testicular cancer

54
Q

CA-15-3

A

breast cancer

55
Q

CA-27-29

A

breast cancer

56
Q

CA-19-9

A

pancreatic adenocarcinoma

57
Q

CA-125

A

ovarian cancer

58
Q

calcitonin

A

medullary thyroid carcinoma

59
Q

CEA

A

nonspecific! Colorectal, pancreatic, gastric, breast and medullary thyroid carcinomas

60
Q

PSA

A

prostate adenocarcinoma, but also BPH and prostatitis

61
Q

S100

A

neural creast origin: melanomas, neural tumors, schwannomas, langerhans cell histiocytosis

62
Q

TRAP

A

hairy cell leukemia - b cell neoplasm

63
Q

EBV

A

burkitt lymphoma, hodgkin lymphoma, nasopharyngeal carcinoma, CNS lymphoma

64
Q

HBV, HCV

65
Q

HHV8

A

kaposi sarcoma, body cavity fluid B-cell lymphoma

66
Q

HPV

A

cervical and penile/anal carcinoma, head, neck and throat cancer

67
Q

H. pylori

A

gastric adenocarcinoma

68
Q

HTLV1

A

adult t-cell leukemia/lymphoma

69
Q

Liver fluke

A

cholangiocarcinoma

70
Q

schistosoma haematobium

A

bladder cancer (squamous cell

71
Q

oncogenic microbes

A

EBV, HBV, HCV, HHV8, HPV, H. pylori, HTLV1, Liver fluke, Shistosoma

72
Q

aflatoxins

73
Q

alkylating agents

A

leukemia, lymphoma

74
Q

aromatic amines

A

transitional cell carcinoma

75
Q

arsenic

A

angiosarcoma (liver), lung cancer, SCC of skin

76
Q

asbestos

A

bronchogenic carcinoma > mesothelioma

77
Q

carbon tetrachloride

A

centrilobular necrosis, fatty change (liver)

78
Q

cigarette smoke

A

transitional cell carcinoma (bladder), SCC and adenocarcinoma (esophagus), renal cell carcinoma, SCC of larynx, squamous cell and small cell carcinoma of lun, pancreatic adenocarcinoma

79
Q

ethanol

80
Q

ionizing radiation

A

papillary thyroid carcinoma

81
Q

nitrosamines

A

gastric cancer

82
Q

radon

A

lung cancer

83
Q

vinyl chloride

A

angiosarcoma of liver

84
Q

1,25-(OH)2 D3 (calcitriol)

A

hodgkin lymphoma, some non-Hodgkin lymphomas

85
Q

ACTH

A

small cell lung carcinoma

86
Q

ADH

A

small cell lung carcinoma and intracranial neoplasms

87
Q

Abs against presynaptic CA2+ channels at NMJ

A

small cell lung carcinoma

88
Q

Erythropoietin

A

renal cell carcinoma, thymoma, hemangioblastoma, HCC, leiomyoma, pheochromocytoma

89
Q

PTHrP

A

Squamous cell lung carcinoma, renal cell carcinoma, breast cancer

90
Q

Psammoma bodies

A

papillary carcinoma of thyroid, serous papillary cystadenocarcinoma of ovary, meningioma, malignant mesothelioma

First Aid (23 decks)

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