obstetric cholestasis Flashcards
1
Q
what
A
reduced outflow of bile acids from liver –> causing them to build up in blood
2
Q
when does it usually develop
A
later in pregnancy , >28wks
3
Q
what is it assoc w
A
increased risk stillbirth
4
Q
presentation
A
pruritus fatigue dark urine pale, greasy stools NO rash
5
Q
Ix
A
LFTs
Bile acids
6
Q
raised ALP in pregnancy
A
normal - placenta produced ALP
a rise in ALP without other abnormal LFT is usually not liver pathoogy
7
Q
Mx
A
ursodeoxycholic acid
emolients
anti-histamines
water soluble VitK if clotting derranged
