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Repro > endometrial pathology > Flashcards

endometrial pathology Flashcards

1
Q

investigation post-menopausal bleeding

A

transvaginal USS

  • endometrial thickness (biopsy >4mm)
  • endometrial contour

endometrial biopsy

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2
Q

pathological prognostic features of endometrial cancer

A

histological type and grade
stage
lymphovascualr space invasion

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3
Q

type 1 endometrial cancer

A

endometrioid adenocarcinoma

commonest

unopposed oestrogen

hyperplasia with atypia precursor

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4
Q

type 2 endometrial cancer

A

uterine serous and clear cell carcinoma

high grade, more aggressive, worse prognosis

serous intraepithelial carcinoma precursor

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5
Q

endometrial cancer staging

A

surgical/pathological

MRI

  • depth myometrial invasion
  • cervical involvement
  • lymph node involvement
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6
Q

stage 1A

A

inner half myometrium

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7
Q

stage 1B

A

outer half myometrium

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8
Q

stage 2

A

invades cervix

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9
Q

stage 3A

A

serosa/adnexa

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10
Q

stage 3B

A

vagina/parametrium]

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11
Q

stage 3C

A

pelvic or para-aortic nodes

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12
Q

stage 4

A

bladder/bowel/intra-abdominal/inguinal nodes

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13
Q

endometrial cancer treatment: early stage

A

surgery TAH + BSO + washings

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14
Q

endometrial cancer treatment: high risk histology

A

chemotherapy beforehand

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15
Q

endometrial cancer treatment: advanced stage

A

radiotherapy

disease control or palliation

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16
Q

endometrial cancer treatment: palliation

A

progesterone

17
Q

who gets endometrial cancer

A

post-menopausal women

high circulating oestrogen levels: obesity, unopposed E2 therapy/tamoxifen, early menarche/late menopause

endometrial hyperplasia with atypia

HNPCC/lynch type II familial cancer syndrome

18
Q

endometrial cancer symptoms

A

abnormal vaginal bleeding

post-menopausal bleeding (PMB)

19
Q

main treatment of endometrial cancer

A

total abdominal hysterectomy with removal of tubes and ovaries + peritoneal washings

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