infections in pregnancy Flashcards

1
Q

chicken pox symptoms

A

fever
malaise
vesicular rash

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2
Q

chicken pox period of infectivity

A

48hrs before onset rash until lesions have crusted over

usually 5-7days

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3
Q

chicken pox and pregnancy risks

A

pregnant women at risk of more severe disease (immunocompromised)
small risk congenital infection in first 28wks
if infected last 4wks pregnancy risk infection in newborn

advise avoid exposure and seek medical advice if do

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4
Q

chicken pox: pregnant woman exposed

A

check immune status - serum IgG
if immune reassure
if no immunity give varicella zoster Ig ASAP

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5
Q

pregnant women gets chicken pox: what to do if mild infection and <24hrs since rash onset

A

oral aciclovir
if >20wks
consider if <20wks

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6
Q

pregnant women gets chicken pox: what to do if mild infection and >24hrs since rash onset

A

aciclovir has no role
symptomatic Rx
hygeine to avoid 2ry bacterial infection

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7
Q

pregnant women gets chicken pox: what to do if severe infection

A

IV aciclovir

hospital admission

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8
Q

parovirus B19

A

spread by resp secretions

fever, rash, erythema of cheeks

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9
Q

what can parovirus B19 infection in pregnancy cause

A

fetal anaemia: cardiac failure, hydrops fetalis, death

maternal eclampsia w significant oedema

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10
Q

if pregnant woman exposed to parovirus B19

A

check immunity - serum Ig

weekly scans to monitor for complications

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11
Q

parovirus B19 critical exposure period in pregnancy

A

12-20wks

fetal infection 5wks after maternal infection

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12
Q

toxoplasmosis

A

protozoa organism toxoplasma gondii

mild-flu like illness: sore throat, arthralgia, coryza, fever

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13
Q

toxoplasmosis severe complications

A

chorioretinitis
encephalitis
myocarditis
pneumonitis

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14
Q

toxoplasmosis when is placental infection possible

A

parasitaemia 3wks after ingestion
placental infection possible during pregnancy and immediately prior to pregnancy

pregnant women told to avoid cat litter trays and undercooked meat

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15
Q

toxoplasmosis congenital infection

A

infection 3rd trimester highest risk

PCR of amniotic fluid can identify toxoplasmosis and confirm congenital infection

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16
Q

toxoplasmosis congenital infection complications

A
hydrocephalus 
intracranial calcifications
microcephaly 
IUGR
ventriculomegaly
hepatosplenomegaly
inc risk misscarriage and IUD
17
Q

HIV increases risk of

A

PET
misscarriage
pre-term delivery
low birth weight

18
Q

HIV: fetal monitoring

A

serial 4wkly fetal growth scans

19
Q

HIV: aims anteretrovirla treatment

A

viral load <50 for vaginal birth
reduce risk vertical transmission
improve mums health

20
Q

HIV: viral load <50

A

vaginal birth

21
Q

HIV: viral load 50-399

A

consider pre-labour CS 38-90wks

22
Q

HIV: viral load 400+

A

prelabour CS 38-39wks recommended

23
Q

babies born to mum w acute hepB infection

A

high risk contracting HBV at birth and risk live chirrhosis and hepatocellular cancer

24
Q

women with chronic HBV infection with high viral load

A

tenovivir monotherapy 1st trimester

25
Q

babies born to HBV +ive mum

A

hepB Ig

accelerated immunisation schedule (at birth, 4wks, 8wks, 12mo)

26
Q

hep C virus

A

RNA virus

can lead to hepatitis, chronic liver disease, inc risk liver Ca

27
Q

indications to offer HCV antenatal screening

A
  • mum IVDU
  • mum past Hx IVDU
  • mum current/prev IVDU partner
  • hepatitis screen due to derranged LFTs
  • mum HIV+ or HBV+
28
Q

HCV Rx in pregnancy

A

none

drugs teratogenic

29
Q

syphilis Rx pregnant woman

A

prompt IM penicillin

30
Q

syphilis increases risk of

A
misscarriage
hydrops fetalis
still birth 
growth restriction 
congenital infection
31
Q

syphilis congenital infection

A

most develop Sx 5wks after birth
hutchinosn’s triad: deaf, interstitial keratitis, hutchinson’s teeth
penicillin

32
Q

how is syphilis spread to baby

A

trans-placentally

lesion exposure at birth