Nucleic acid Flashcards
nucleoside
precursor of nucleotide
consist of base + ribose - 2’ deoxyribose
nucleic acid
base + ribose + phosphate group
RNA - not OH on 2’ of ribose
Uracil base
does not have Me from thymidine (stability of thymidine)
Me
methyl
Na
nucleic acid
chemistry of acid - 2NA - nucleotide triphosphates - sorting material for synthesis
3’ OH from one NA - nucleophile - carries e- and phosphorus from NA (electrophile) - accepts e- from O in 1
bond between phosphorus and O - break diphosphate
DNA characteristics for phosphorus etc
salt of phosphoric acid ester - dissolves in water
5’ to 3’ direction
contain different genetic info
duplex structure
geometric complementary + H bonding
sorting (Ds DNA) and translation (make protein)
coil and compact into small spaces
Watson-Crick base pairs
pseudo symmetric = regular double helix
nucleic acid chirality
determined by compacting mirror image of OG molecule and see if they are superimposable
not imposable
mirror image rotated to match but doesn’t
nucleoside is chiral
helix being chiral
chiral molecules forming higher structures
RH double helix - specificity
recognise one type of chiral
has specificity for making chirality
