NT Clostridium Flashcards
1
Q
General features
A
- spore forming
- gram +ve
- anaerobic
- toxin prod.
2
Q
3 classifications of clostridium
A
- Histotoxic
- neurotoxic
- enterotoxic
3
Q
Toxins
A
- can be pre-formed
- can be produces @ site of tissue damage or alteration of microenvironment
4
Q
Name neurotoxic clostridia (2)
A
C. Botulinum
C. Tetani
5
Q
C. Tetani characteristics
A
- gram +ve, rod/ drumstick shaped, obligate anaerobe
- high mortality rate
- etiologic agent of tetanus/lockjaw
6
Q
Natural habitat of C. Tetani
A
Soil & GIT
7
Q
Which spp are more susceptible to tetanus?
A
Horses(MAIN), ruminants, and swine
8
Q
What is tetanus?
A
- neuroparalytic toxication caused by tetanospasmin
- causes tonic-clonic convulsions & spastic paralysis
- organism enters via wounds/abrasions, surgical incisions, dockings, castrations, injection sites, etc
9
Q
Why are deep wounds and necrosis favorable environments for clostridium
A
Bc environment is reduced O2
10
Q
Characteristics of C. Botulinum
A
- Obligate anaerobe, sub-terminal oval spores
- spores in soil & plants
- 1 mcg can kill person
11
Q
C. Botulinum causes
A
Botulism (neuroparalytic intox. & flaccid paralysis
12
Q
Toxicoinfection definition
A
Organism multiplies INSIDE HOST
13
Q
Intoxication definition
A
Organism is pre-formed, then ingested
14
Q
Toxicoinfectious botulism causes
A
- floppy baby syndrome
15
Q
In which species is botulism seen in
A
Ruminants, waterfowl, horses
