Mycoses Of Veterinary Importance Flashcards

1
Q

Thermally monomorphic mold is

A

Aspergillus

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2
Q

What do aspergillus colonies look like

A
  • white at first
  • then yellow, green, brown, or black
  • velvety or cottony
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3
Q

Microscopic characteristics of aspergillus

A
  • Septate hyphae and unbranched conidiophore that form a foot cell
  • vesicles
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4
Q

What are often seen in culture preps of aspergillus

A

Chains of round conidia

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5
Q

Where does aspergillus affect K9s and horse?

A
  • K9: nose
  • horse: guttural pouch
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6
Q

Main type of aspergillus

A

A. fumigatus

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7
Q

Aspergillus infections

A
  • by inhalation
  • first airway infected (local inflamm. Resp)
  • then potentially lethal invasive infection in immunocomp.
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8
Q

Yeast that is normal inhabitant of upper GIT and moist skin folds

A

Candida

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9
Q

Is candida local or systemic?

A

Both

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10
Q

A major nosocomial yeast is called

A

Candida

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11
Q

T or F: Candida can grow in the body as yeasts w/ pseudohyphae

A

True

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12
Q

Most common candida spp

A

C. albicans

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13
Q

Emerging spp of candida

A

C. auris

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14
Q

Candida auris

A
  • drug resistant (multi)
  • rapidly spreading, especially in healthcare facilities
  • hard to ID
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15
Q

Pythium insidiosum causes what disease

A

Pythiosis

(Aka: swamp cancer, florida horse leeches, canckers, etc.)

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16
Q

2 forms of pythium insidiosum

A
  • GIT
  • Cutaneous
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17
Q

Areas where pythium insidiosum is common

A

Gulf coast & SE USA

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18
Q

Where do the spores of pythium insidiosum infect?

A
  • lower extremities of exposed skin
  • ingested w/ contaminated h2o
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19
Q

What is pythium insidiosum

A

Granulomatous ulcerative disease of skin and GIT

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20
Q

What zygomycetes cause zygomycosis

A
  • mortierella
  • absidia

Mucor

  • rhizopus
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21
Q

T or F: Pythium insidiosum is motile

22
Q

Characteristics of zygomycetes

A
  • aseptate hyphae
  • grow fast
23
Q

What specific diseases can zycomycetes cause?

A
  • gastritis in bovines
  • mycotic abortion & placentitis in ruminants
  • guttural pouch & cervico-uterine infections in horses
24
Q

Why is the spread of zygomcyosis fatal

A
  • angio-invasion
  • thrombosis
25
Antifungal drugs
- polyene - imidazole - 5-fluorocytocine - griseofulvin - terbinafine - caspofungin
26
Polyene drugs
- target ergosterol - ex: aphotericin b & nystatin
27
Imidazole drugs
- ergesterol synthesis is target - ex: “-azole” group; ketoconazole, fluconazole, etc)
28
5-fluorocytocine
DNA synthesis inhibitor
29
Griseofulvin
- binds tubulin - interferes with/ fungal mitosis - conc. In epith. - teratogenic
30
Terbinafine
Ergosterol synth inhibitor
31
Caspofungin
Glucan synthase inhibitor
32
Yeast don’t have
Hyphae
33
Mold has
Spores
34
Characteristics of fungi
- eukaryotic - cell wall has glucan and chitin - cell membrane has ergosterol (other “-sterols”)
35
Difference between mycoses & mycotoxins
- mycoses: grows inside host - mycotoxins: grows outside the host
36
Importance of mycoses
- diagnosed late or misdiagnosed b/c signs are non-specific or insuff. culture sensitivity - immunosupp. Patients get disseminated mycoses - long term abx can eliminate/reduce bacterial load - tx challenging
37
What mediums can fungi grow on as a mold or yeast
SDA
38
Fungi that affect skin/SQ
- Microsporum spp. - Trichophyton spp. - malassezia pachydermatis - sporothrix schenkii
39
Fungi that infect systemically
- histoplasma capsulatum - blastomyces dermatidis - coccidioides immitis - cryptococcus neoformans
40
Opportunistic fungi
- aspergillus fumigatus - candida albicans & auris
41
Dermatomycoses is also known as
Ring worm
42
What are the trichophyton that cause ring worm in large animals?
- T. Verrucosum (cattle) - T. Rubrum (humans) - T. Mentagrophytes (horses)
43
Microsporum canis
- zoophilic dermatophyte - affects small animals
44
Non-dermatophytes spp.
Malassezia pachydematis & M. Nana
45
Dermatophytes is grown on
DTM
46
How to dx dermatophytes
- wood’s lamp (only for M. Canis) - hair/skin specimen microscopy - culture and ID - KOH mount
47
KOH mount
- not really used, only by experts - look for ectothrix formation - look for arthrospores surrounding/on hair
48
Malassezia & otitis/dermatitis
- normal flora of man and animals - M. Pachydermatis & M. Nana found in animals - commensalistic in normal subjects - disease caused by host related factors - elephant skin
49
Sporotrichoisis
- agent: S. schenkii (dimorphic) - found in N & S America - SQ invasive mycosis - aka: rose-gardener’s disease
50
Sporothrix schenkii microscopic characteristics
- colonies are small and white w/o cottony aerial hyphae - later colonies become moist, velvety, and darkly - septate, thin, branching, hyphae @ right angles - conidia are pear shaped in clusters - cigar bodies