NSAIDs

Question 1

Opioids

Answer 1

codeine
fentanyl
methadone
morphine
oxycodone
oxymorphone
tramadol

Question 2

NSAID types

Answer 2

Mechanism of action:
- Inhibits the synthesis of prostaglandins by inhbiting cyclooxygenase, present as COX 1 and COX 2
- COX 1 inhibition results in impaired gastric cyto-protection and antiplatelet effects
- COX 2 inhibition results in anti-inflammatory and analgesic effects
-**
1. Non-selective NSAIDs (inhibits COX 1 and COX 2)**
- Aspirin
- Ibuprofen
- Diclofenac
-
2. Selective (inhibits COX 2 only)
- Parecoxib
- Celecoxib

**Precautions:
- Peptic ulcer disease
- Active bleeding
- Asthma - can cause bronchospasms
-
Adverse effects:
- GI ulcerations
- Increased bleeding risk
- Nausea
- Dispepsia
- Vomiting

Question 3

list your knowlege about asprin

Answer 3

Aspirin
Type: Non-selective NSAID
Indication:
- Mild to moderate pain
Mechanism of action:
- Inhibits COX1 and COX 2, which prevents synthesis of prostaglandins (involved in inflammatory response)
Dosage:
- typically 300-900mg every 4-6 hours
- low doses at 100mg cause antiplatelet effects
Adverse effects:
- nausea, vomiting, dyspepsia, GI bleeding and ulceration
Contraindications:
- GI ulcers
- active bleeding
- NSAID allergy

Question 4

Paracetamol

Answer 4

Indication:
- mild to moderate pain
- fever
Mechanism of action:
- not fully understood
- may involve central postroaglandin synthesis and inhibition of serotonergic pathways
Adverse effects:
- well tolerated
- hypersensitivity, rash, Stevens-Johnsons syndrome
Contrainidications:
- hepatoxicity in overdose (liver disease)
Pregnancy and breastfeeding:
- safe