Non-ossifying Fibroma

Question 1

What is the most common benign tumor in pediatric patients?

Answer 1

Non-ossifying fibroma;

80% occur in lower extremity; distal femur and proximal tibia metaphysis

Question 2

What is Jaffe-Campanacci syndrome?

Answer 2

1) multiple non-ossifying fibromas
2) mental retardation
3) cafe-au lait spots
4) Heart, eye, gonadal involvement

Question 3

What are imaging and histologic characteristics of non-ossifying fibroma?

Answer 3

1) eccentric lesion with “bubbly” appearance on xray
2) fibroblastic cells in whirlwind appearance (helicopter in wheat field)
3) hemosiderin staining

Question 4

What is the treatment for non-ossifying fibroma?

Answer 4

observation for most lesions, casting for fractures, currettage for some larger lesions