Chemotherapy Flashcards
1
Q
What is the mechanism of action of chemotherapy?
A
1) Induces apoptosis
2) Can target specific over-expressed proteins (eg tyrosine kinase)
2
Q
What orthopedic cancers is chemotherapy an integral part?
A
1) Osteosarcoma
2) Ewing’s
3) Malignant fibrous histiocytome (MFH)
4) high grade chondrosarcoma
5) Controversial in soft tissue sarcoma
3
Q
What is the general administration of chemotherapy?
A
Pre-op for 8-12 weeks
Post-op for 6-12 months
4
Q
Doxorubicin (Adriamycin), a common chemotherapeutic agent used in the treatment of osteosarcoma, has which of the following major dose-limiting toxicities?
A
Cardiac toxicity (7%)
Ifosfamide- neurological toxicity like encephalopathy.
Cyclophosphamide- myelosuppression and urotoxicity.
Bleomycin- pulmonary fibrosis.
