NMJ/CIS - Iszard 2017

Question 1

What is the mechanism of actin of Tetrodotoxin? 11

Answer 1

Blocks diffusion of sodium through the sodium channel

Prevents depolarization/propagation of action potentials in nerve cells

Question 2

What is the mechanism of action of Botulinum toxin? 15

Answer 2

Prevents the release of acetylcholine from axon endings at the NMJ

Causes flaccid paralysis

Question 3

What is the consequence of tetanus toxin exposure? 18

Answer 3

Causes lockjaw

Causes severe muscle cramps after traveling to the spinal cord

Question 4

What is the mechanism of action of Tetanus toxin? 19

Answer 4

Blocks the release of inhibitory neurotransmitters:
γ-aminobutyric acid
Glycine

Question 5

What is the mechanism of action of Curare Alkaloids? 20

Answer 5

Physiology:
Competes with acetylcholine

Blocks Transmission of information

Question 6

What is the physiology and mechanism of action of Succinylcholine (anectine)? 22

Answer 6

Physiology —> Prevents muscles from contracting

Action —>
Paralysis of respiratory muscles
Paralysis of moving muscles

Question 7

What is the mechanism of action and physiology of Danrolene? 24

Answer 7

Action:
Prevents/reduces high body temperature

Physiology:
Muscle relaxant

Restores normal levels of Ca2+ in muscles